Vincent M. Christoffels

Amsterdam University Medical Centers — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

74h-index17.9kcitations327works5.22yr avg
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Research Topics

Congenital heart defects research(194), Cardiomyopathy and Myosin Studies(66), Cardiac electrophysiology and arrhythmias(51), Congenital Heart Disease Studies(46), RNA Research and Splicing(30)

Publications325 total

<i>Zeb2os</i> Hinders Cardiac Healing by Suppressing ZEB2 Reactivation and Cardiomyocyte Dedifferentiation
Circulation Research·2026· 1 citedOpen Access
PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias
Nature Communications·2025Open Access
AAV6-based ZEB2 delivery promotes cardiomyocyte dedifferentiation in adult human myocardium
Cardiovascular Research·2025· 1 citedOpen Access
<i>Hand1</i> gene replacement with <i>Hand2</i> reveals overlap in function with unique occurrence of omphalocele and heart defects
Development·2025· 1 citedOpen Access
Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2
2025Open Access
AAV6-HCN4t-mediated biological pacing as a potential life-saving therapy for congenital complete heart block
2025Open Access
AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration
Molecular Therapy — Methods & Clinical Development·2025· 2 citedOpen Access
BS-499652-005 AAV-HCN4T-MEDIATED BIOLOGICAL PACING AS A POTENTIAL LIFE-SAVING THERAPY FOR CONGENITAL COMPLETE HEART BLOCK
Heart Rhythm·2025Open Access
<i>SCN10A-short</i> gene therapy to restore conduction and protect against malignant cardiac arrhythmias
European Heart Journal·2025· 13 citedOpen Access
The trabecular and compact myocardium of adult vertebrate ventricles are transcriptionally similar despite morphological differences
Annals of the New York Academy of Sciences·2025· 2 citedOpen Access
The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis
Nature Communications·2025· 22 citedOpen Access
Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration
Nature Cardiovascular Research·2025· 10 citedOpen Access
Author response for "The trabecular and compact myocardium of adult vertebrate ventricles are transcriptionally similar despite morphological differences"
2024
Author response for "The trabecular and compact myocardium of adult vertebrate ventricles are transcriptionally similar despite morphological differences"
2024
A Rare Noncoding Enhancer Variant in <i>SCN5A</i> Contributes to the High Prevalence of Brugada Syndrome in Thailand
Circulation·2024· 11 citedOpen Access
Modeling the atrioventricular conduction axis using human pluripotent stem cell-derived cardiac assembloids
Cell stem cell·2024· 27 citedOpen Access
The Impact of Natriuretic Peptides on Heart Development, Homeostasis, and Disease
Cells·2024· 17 citedOpen Access
PO-05-204 LONG-TERM TBX18 OVEREXPRESSION AT NON-CYTOTOXIC LEVELS INDUCES ABNORMAL AUTOMATICITY BY DESTABILIZING RESTING MEMBRANE POTENTIAL
Heart Rhythm·2024
HCN2-based biological pacing in a modified rat AV-block model
Cardiovascular Research·2024Open Access
PO-05-203 AAV6-MEDIATED GENE TRANSFER OF HCN1-ΔΔΔ GENERATES MORE POTENT PACING THAN HCN2 YET WITH A POTENTIAL RISK FOR PRO-ARRHYTHMIA
Heart Rhythm·2024Open Access
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Frequent Co-authors

Antoon F.M. Moorman(28), Andreas Kispert(11), Mathilda T.M. Mommersteeg(8), Corrie de Gier-de Vries(8), Bastiaan J. Boukens(7), Phil Barnett(7), Willem M.H. Hoogaars(6), Vincent Wakker(6), Arie O. Verkerk(5), Martijn L. Bakker(5), Danielle E.W. Clout(5), Julia Norden(5), Connie R. Bezzina(4), Cornelia Wiese(4), Marina Campione(4), Richard P. Harvey(4), Nigel A. Brown(4), Robert H. Anderson(4), Maurice J.B. van den Hoff(4), Thomas Grieskamp(4)