G. Cseke

Heptares Therapeutics (United Kingdom) — United Kingdom

Chemistry · Physical Sciences

9h-index475citations19works0.02yr avg
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Research Topics

Free Radicals and Antioxidants(8), Sleep and Wakefulness Research(6), Neuropeptides and Animal Physiology(5), Eicosanoids and Hypertension Pharmacology(5), Receptor Mechanisms and Signaling(4)

Publications19 total

Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode
ACS Medicinal Chemistry Letters·2022· 1 citedOpen Access
Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein–Ligand Complexes
ACS Chemical Neuroscience·2022· 9 cited
Structure-Based Drug Discovery of <i>N</i> -(( <i>R</i> )-3-(7-Methyl-1 <i>H</i> -indazol-5-yl)-1-oxo-1-((( <i>S</i> )-1-oxo-3-(piperidin-4-yl)-1-(4-(pyridin-4-yl)piperazin-1-yl)propan-2-yl)amino)propan-2-yl)-2′-oxo-1′,2′-dihydrospiro[piperidine-4,4′-pyrido[2,3- <i>d</i> ][1,3]oxazine]-1-carboxamide (HTL22562): A Calcitonin Gene-Related Peptide Receptor Antagonist for Acute Treatment of Migraine
Journal of Medicinal Chemistry·2020· 17 citedOpen Access
Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis
Journal of Medicinal Chemistry·2019· 75 citedOpen Access
Crystal structure of the Orexin-1 receptor in complex with Compound 14
2019
Crystal structure of the Orexin-1 receptor in complex with Compound 16
2019· 28 citedOpen Access
Crystal structure of the Orexin-1 receptor in complex with SB-334867
2019
Crystal structure of the Orexin-1 receptor in complex with SB-408124
2019
Crystal structure of the Orexin-2 receptor in complex with suvorexant at 2.76 A resolution
2019
Crystal structure of the Orexin-2 receptor in complex with HTL6641 at 2.61 A resolution
2019
Crystal structure of the Orexin-1 receptor in complex with ACT-462206
2019
Crystal structure of the Orexin-1 receptor in complex with GSK1059865
2019
Crystal structure of the Orexin-1 receptor in complex with suvorexant at 2.29 A resolution
2019
Crystal structure of the Orexin-1 receptor in complex with lemborexant
2019
A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines
Biochemical Pharmacology·2017· 11 citedOpen Access
Monoclonal anti-β<sub>1</sub>-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment
mAbs·2013· 37 citedOpen Access
Integrin αvβ1 promotes infection by human metapneumovirus
Proceedings of the National Academy of Sciences·2009· 112 citedOpen Access
A Recombinant Human Monoclonal Antibody to Human Metapneumovirus Fusion Protein That Neutralizes Virus In Vitro and Is Effective Therapeutically In Vivo
Journal of Virology·2007· 89 citedOpen Access
Human Metapneumovirus Fusion Protein Vaccines That Are Immunogenic and Protective in Cotton Rats
Journal of Virology·2006· 96 citedOpen Access

Frequent Co-authors

Miles Congreve(14), J.A. Christopher(13), S.J. Bucknell(12), Ali Jazayeri(12), Fiona H. Marshall(12), Mathieu Rappas(11), A. Ali(11), K.A. Bennett(11), Roger Cooke(11), Chris de Graaf(11), James C. Errey(11), Richard F. Mould(11), Jayesh C. Patel(11), B.G. Tehan(10), M. Weir(10), J. D. Brown(9), J.S. Mason(9), A.S. Dore(6), Jason Brown(5), Antonio Dore(5)