Wei‐Ru Huang

National Chung Hsing University — Taiwan

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index802citations37works1.22yr avg

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Research Topics

Virus-based gene therapy research(17), Viral gastroenteritis research and epidemiology(11), Animal Virus Infections Studies(6), RNA modifications and cancer(5), Viral Infectious Diseases and Gene Expression in Insects(5)

Publications37 total

The oncolytic avian reovirus p17 protein triggers chaperone-mediated autophagy by modulating Hsp90 and the T-complex protein-1 ring complex chaperones and co-chaperones to activate the IKK/NF-κB signaling

Journal of Virology·2025Open Access

Avian reovirus induces autophagy-mediated cargo of progeny viruses to extracellular vesicles and enhancement of virus release

2 cited

Veterinary Microbiology·2025· 2 cited

Oncolytic avian reovirus regulates the TLR3-IRF3-IFN-γ-JAK-STAT1 and TLR3-NF-κB-IFN-γ-JAK-STAT1 pathways inducing autophagy in murine melanoma cells

2 cited

Veterinary Microbiology·2025· 2 cited

The oncolytic avian reovirus p17 protein suppresses invadopodia formation via disruption of TKs5 complexes and oncogenic signaling pathways

1 cited

Frontiers in Cellular and Infection Microbiology·2025· 1 citedOpen Access

Correction for Huang et al., “p17-Modulated Hsp90/Cdc37 Complex Governs Oncolytic Avian Reovirus Replication by Chaperoning p17, Which Promotes Viral Protein Synthesis and Accumulation of Viral Proteins σC and σA in Viral Factories”

1 cited

Journal of Virology·2024· 1 citedOpen Access

Development of Polycistronic Baculovirus Surface Display Vectors to Simultaneously Express Viral Proteins of Porcine Reproductive and Respiratory Syndrome and Analysis of Their Immunogenicity in Swine

2 cited

Vaccines·2023· 2 citedOpen Access

Cell Entry of Avian Reovirus Modulated by Cell-Surface Annexin A2 and Adhesion G Protein-Coupled Receptor Latrophilin-2 Triggers Src and p38 MAPK Signaling Enhancing Caveolin-1- and Dynamin 2-Dependent Endocytosis

12 cited

Microbiology Spectrum·2023· 12 citedOpen Access

Oncolytic Avian Reovirus σA-Modulated Upregulation of the HIF-1α/C-myc/glut1 Pathway to Produce More Energy in Different Cancer Cell Lines Benefiting Virus Replication

11 cited

Viruses·2023· 11 citedOpen Access

Oncolytic avian reovirus σA‐modulated fatty acid metabolism through the PSMB6/Akt/SREBP1/acetyl-CoA carboxylase pathway to increase energy production for virus replication

11 cited

Veterinary Microbiology·2022· 11 cited

Oncolytic Avian Reovirus p17-Modulated Inhibition of mTORC1 by Enhancement of Endogenous mTORC1 Inhibitors Binding to mTORC1 To Disrupt Its Assembly and Accumulation on Lysosomes

13 cited

Journal of Virology·2022· 13 citedOpen Access

p17-Modulated Hsp90/Cdc37 Complex Governs Oncolytic Avian Reovirus Replication by Chaperoning p17, Which Promotes Viral Protein Synthesis and Accumulation of Viral Proteins σC and σA in Viral Factories

20 cited

Journal of Virology·2022· 20 citedOpen Access

Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.

8 cited

PubMed·2022· 8 citedOpen Access

Molecular chaperone TRiC governs avian reovirus replication by protecting outer-capsid protein σC and inner core protein σA and non-structural protein σNS from ubiquitin- proteasome degradation

12 cited

Veterinary Microbiology·2021· 12 cited

Involvement of TRPC7-AS1 Expression in Hepatitis B Virus-Related Hepatocellular Carcinoma

15 cited

Journal of Oncology·2021· 15 citedOpen Access

Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy

10 cited

Frontiers in Immunology·2020· 10 citedOpen Access

Construction of polycistronic baculovirus surface display vectors to express the PCV2 Cap(d41) protein and analysis of its immunogenicity in mice and swine

19 cited

Veterinary Research·2020· 19 citedOpen Access

Baculovirus surface display of the HA protein of H5N2 avian influenza virus and its immunogenicity against a lethal challenge with H5N1 virus in chickens

16 cited

Veterinary Microbiology·2020· 16 cited

Correction: The p17 nonstructural protein of avian reovirus triggers autophagy enhancing virus replication via activation of phosphatase and tensin deleted on chromosome 10 (PTEN) and AMP-activated protein kinase (AMPK), as well as dsRNA-dependent protein kinase (PKR)/eIF2 α signaling pathways.

2 cited

Journal of Biological Chemistry·2019· 2 citedOpen Access

Heterogeneous Nuclear Ribonucleoprotein A1 and Lamin A/C Modulate Nucleocytoplasmic Shuttling of Avian Reovirus p17

29 cited

Journal of Virology·2019· 29 citedOpen Access

Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis

40 cited

Veterinary Microbiology·2019· 40 cited

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Frequent Co-authors

Hung‐Jen Liu(33), Tsai‐Ling Liao(16), Brent L. Nielsen(14), Jyun‐Yi Li(10), Hung‐Chuan Chiu(9), Chi-Young Wang(7), Chao‐Yu Hsu(7), Pei I.(5), Kuo‐Pin Chuang(5), Ching‐Dong Chang(5), Yi-Ying Wu(5), Yu-Kang Chang(5), Pei-I Chi(4), Wing-Ling Shih(3), Muhammad Munir(3), Hsiao‐Wei Wen(3), Lon‐Fye Lye(3), Ching Yuan Cheng(2), Lai Wang(2), Hung‐Yi Wu(2)