Israel Silman

Weizmann Institute of Science — Israel

Medicine · Health Sciences

82h-index29.6kcitations434works3.02yr avg
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Research Topics

Cholinesterase and Neurodegenerative Diseases(275), Computational Drug Discovery Methods(187), Enzyme function and inhibition(59), Pesticide Exposure and Toxicity(50), Chemical synthesis and alkaloids(43)

Publications434 total

Why is binding of a divalent metal cation to a structural motif containing four carboxylate residues not accompanied by a conformational change?
Protein Science·2024· 3 citedOpen Access
The impact of molecular variants, crystallization conditions and the space group on ligand–protein complexes: a case study on bacterial phosphotriesterase
Acta Crystallographica Section D Structural Biology·2023· 1 citedOpen Access
Cover Image, Volume 91, Issue 8
Proteins Structure Function and Bioinformatics·2023Open Access
The impact of molecular variants, crystallization conditions and space group on structure-ligand complexes: A case study on Bacterial Phosphotriesterase Variants and complexes
2023Open Access
Do “Newly Born” orphan proteins resemble “Never Born” proteins? A study using three deep learning algorithms
Proteins Structure Function and Bioinformatics·2023· 15 citedOpen Access
Design of a stable human acid‐β‐glucosidase: towards improved Gaucher disease therapy and mutation classification
FEBS Journal·2023· 16 citedOpen Access
Author response for "Design of a stable human acid‐β‐glucosidase: towards improved Gaucher disease therapy and mutation classification"
2023
Do Newly Born Orphan Proteins Resemble Never Born Proteins? A Study using Deep Learning Algorithms
2022· 4 cited
Do Newly Born Orphan Proteins Resemble Never Born Proteins? A Study Using Three Deep Learning Algorithms
2022Open Access
Preface: Cholinergic mechanisms
Journal of Neurochemistry·2021Open Access
<i>Torpedo californica</i> acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif
Protein Science·2021· 9 citedOpen Access
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
Journal of Medicinal Chemistry·2020· 88 citedOpen Access
The multiple biological roles of the cholinesterases
Progress in Biophysics and Molecular Biology·2020· 65 cited
Computational studies on cholinesterases: Strengthening our understanding of the integration of structure, dynamics and function
Neuropharmacology·2020· 12 cited
A Second Look at the Crystal Structures of Drosophila melanogaster Acetylcholinesterase in Complex with Tacrine Derivatives Provides Insights Concerning Catalytic Intermediates and the Design of Specific Insecticides
Molecules·2020· 30 citedOpen Access
Polyproline-rich peptides associated with Torpedo californica acetylcholinesterase tetramers
Chemico-Biological Interactions·2020· 2 citedOpen Access
Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor
ACS Medicinal Chemistry Letters·2020· 11 citedOpen Access
CCDC 1981218: Experimental Crystal Structure Determination
The Cambridge Structural Database·2020Open Access
Molecular dynamics simulations of the interaction of Mouse and Torpedo acetylcholinesterase with covalent inhibitors explain their differential reactivity: Implications for drug design
Chemico-Biological Interactions·2019· 14 cited
The four-helix bundle in cholinesterase dimers: Structural and energetic determinants of stability
Chemico-Biological Interactions·2019· 8 cited
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Frequent Co-authors

Joel L. Sussman(39), Michal Harel(18), Gitay Kryger(7), Dan S. Tawfik(6), Anthony H. Futerman(6), Lilly Toker(5), Hay Dvir(5), Harry M. Greenblatt(5), Terrone L. Rosenberry(4), Charles B. Millard(4), Paul H. Axelsen(3), Amir Aharoni(3), Raimond B. G. Ravelli(3), Moshe Goldsmith(3), Yacov Ashani(3), Martin H. Weik(3), Avigdor Shafferman(3), M G Low(3), Felix Frolow(2), Adrian Goldman(2)