William G. Devine

Northeastern University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index771citations36works3.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(9), PI3K/AKT/mTOR signaling in cancer(9), Research on Leishmaniasis Studies(8), Trypanosoma species research and implications(8), Synthesis and Biological Evaluation(8)

Publications36 total

Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents
ACS Infectious Diseases·2025Open Access
Novel Small-Molecule ROCK2 Inhibitor GNS-3595 Attenuates Pulmonary Fibrosis in Preclinical Studies
American Journal of Respiratory Cell and Molecular Biology·2024· 6 cited
Supplementary Figure from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Supplementary Figure from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Supplementary Figure from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Supplementary Figure from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Data from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Supplementary Data from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Supplementary Data from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Data from Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
2023Open Access
Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity
Molecular Cancer Therapeutics·2022· 7 citedOpen Access
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML
Leukemia·2021· 40 citedOpen Access
Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F
Cell Reports·2020· 73 citedOpen Access
Structure–property studies of an imidazoquinoline chemotype with antitrypanosomal activity
RSC Medicinal Chemistry·2020· 4 citedOpen Access
Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors
Cell chemical biology·2019· 74 citedOpen Access
Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas
Leukemia·2019· 30 citedOpen Access
Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation
Scientific Reports·2019· 10 citedOpen Access
Inhibition of Translation Initiation and Heat Shock Factor 1 (HSF1): A Novel Strategy Targeting FLT3 Double Mutant and Non-FLT3 Mutant AML Progenitor/Stem Cells
Blood·2017
Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma
Science Translational Medicine·2017· 71 citedOpen Access
Antiparasitic Lead Discovery: Toward Optimization of a Chemotype with Activity Against Multiple Protozoan Parasites
ACS Medicinal Chemistry Letters·2017· 26 cited
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Frequent Co-authors

John A. Porco(18), Lauren E. Brown(14), Jerry Pelletier(12), Michael P. Pollastri(9), Stacey L. Lehman(9), Theresa Wechsler(9), Kayla Schwartz(9), Uma Shankavaram(9), Kevin Camphausen(9), Philip J. Tofilon(9), Nicholas E. Leadbeater(5), Jessey Erath(4), Luke Whitesell(4), Jennifer Chu(3), Wenhan Zhang(3), Regina Cencic(3), Emanuele Amata(3), Susan E. Leed(3), Ana Rodrı́guez(3), Kojo Mensa‐Wilmot(3)