Adriano Aguzzi

University Hospital of Zurich — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

124h-index61.0kcitations879works12.42yr avg
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Research Topics

Prion Diseases and Protein Misfolding(467), Neurological diseases and metabolism(196), Trace Elements in Health(145), Alzheimer's disease research and treatments(75), Neuroinflammation and Neurodegeneration Mechanisms(48)

Publications878 total

Altered Crosstalk of Bacterial Lipopolysaccharide with Immune Cells in Colorectal Cancer Compared to Paired Adjacent Intestinal Tissue
2026Open Access
Lysosomal escape and TMEM106B fibrillar core determine TDP-43 seeding outcomes
2025Open Access
Prime editing of the β1 adrenoceptor in the brain restores physiological REM sleep in a mouse model of Alzheimer’s disease
Nature Communications·2025Open Access
Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity
Universität Zürich, ZORA·2025Open Access
Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity
PLoS Biology·2025Open Access
The Bone Morphogenetic Pathway Controls the Uptake of Infectious Prions
2025Open Access
Structure-function relationship of alpha-synuclein fibrillar polymorphs derived from distinct synucleinopathies
2025· 1 citedOpen Access
Ablation of progranulin augments microglial activation and accelerates prion progression
Acta Neuropathologica Communications·2025Open Access
A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma
Cancer Cell·2025
04PNovel mouse model for inclusion body myositis: transgenic upregulation of lymphotoxin together with impaired autophagy induces inflammation and protein accumulation in skeletal muscle
Neuromuscular Disorders·2025Open Access
Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle
Brain·2025Open Access
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Neuron·2025· 4 citedOpen Access
Age-Related Gliosis Promotes Central Nervous System Lymphoma through CCL19-Mediated Tumor Cell Retention
Cancer Cell·2025· 3 cited
Large-scale bidirectional arrayed genetic screens identify <i>OXR1</i> and <i>EMC4</i> as modifiers of α-synuclein aggregation
2025· 2 cited
Correction for Ligios et al., “Sheep with Scrapie and Mastitis Transmit Infectious Prions through the Milk”
Journal of Virology·2025· 1 citedOpen Access
aDISCO: A clearing method to enable 3D microscopy of large archival paraffin-embedded human tissue blocks
2025· 1 citedOpen Access
Quantitative 3D histochemistry reveals region-specific amyloid-β reduction by the antidiabetic drug netoglitazone
PLoS ONE·2025Open Access
Endothelial CCR2 Signaling Induced by Colon Carcinoma Cells Enables Extravasation via the JAK2-Stat5 and p38MAPK Pathway
Cancer Cell·2025· 1 citedOpen Access
Seeded aggregation of TDP-43 induces its loss of function and reveals early pathological signatures
Neuron·2025· 19 citedOpen Access
Accelerating Biomedical Discoveries in Aging and Neurodegeneration Through Transformative Neuropathology
Preprints.org·2025· 1 citedOpen Access
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Frequent Co-authors

Charles Weissmann(6), Frank L. Heppner(5), Thomas Rülicke(5), Michael A. Klein(4), Markus Glatzel(4), Mathias Heikenwälder(4), Andreas W. Sailer(3), Marco Prinz(3), Alex J. Raeber(3), Sebastian Brandner(3), Erwin F. Wagner(3), Magdalini Polymenidou(3), Ulrich Kalinke(3), Hans A. Kretzschmar(3), Herbert Budka(3), Christina J. Sigurdson(3), Rolf M. Zinkernagel(3), Juliane Bremer(3), Petra Schwarz(3), Michel Aguet(2)