Joris Deelen

Loyola University Medical Center — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

62h-index21.3kcitations235works4.82yr avg
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Research Topics

Genetic Associations and Epidemiology(50), Genetics, Aging, and Longevity in Model Organisms(48), Epigenetics and DNA Methylation(46), Diet and metabolism studies(25), Birth, Development, and Health(24)

Publications227 total

Rare longevity-associated variants, including a reduced-function mutation in cGAS, identified in multigenerational long-lived families
2025Open Access
Open problems in ageing science: a roadmap for biogerontology
GeroScience·2025· 5 citedOpen Access
Blood Proteomic Biomarkers indicate reduced system and tissue level inflammation responses to The GOTO Lifestyle Intervention in Older Adults
2025Open Access
[Molecular biomarkers of biological age; how we can use them, now and in the future].
PubMed·2025
Extreme MetaboHealth scores in three cohort studies associate with plasma protein markers for inflammation and cholesterol transport
Immunity & Ageing·2025· 1 citedOpen Access
eLife Assessment: Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2025Open Access
Open problems in ageing science: A roadmap for biogerontology
arXiv (Cornell University)·2025· 1 citedOpen Access
eLife Assessment: Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2025Open Access
Functional characterisation of rare variants in genes encoding the MAPK/ERK signalling pathway identified in long-lived Leiden Longevity Study participants
GeroScience·2025· 1 citedOpen Access
The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan
Nature Aging·2025· 21 citedOpen Access
Heritability of human lifespan is about 50% when confounding factors are addressed
2025· 4 citedOpen Access
German longevity study reveals novel rare pro-longevity alleles clustering in mTOR signaling pathway
GeroScience·2025· 2 citedOpen Access
eLife Assessment: Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2025Open Access
Unanswered questions in ageing: an interview with Dr Joris Deelen
The Biochemist·2024Open Access
The MetaboHealth score enhances insulin resistance metabotyping for targeted fat loss through personalized diets: Insights from the PERSON intervention study
2024· 2 citedOpen Access
eLife assessment: Statistical examination of shared loci in neuropsychiatric diseases using genome-wide association study summary statistics
2024Open Access
Exploring the Interplay between Carotenoids, Lipid Oxidation, and Cognitive Impairment in Aging
Alzheimer s & Dementia·2024· 1 citedOpen Access
HETEROGENEOUS METABOLOMIC AGING ACROSS THE SAME AGE AND PEDICTION OF HEALTH OUTCOME
Innovation in Aging·2024Open Access
Disagreement on foundational principles of biological aging
PNAS Nexus·2024· 39 citedOpen Access
eLife Assessment: Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans
2024Open Access
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Frequent Co-authors

Marian Beekman(37), P. Eline Slagboom(37), Dorret I. Boomsma(23), Cornelia M. van Duijn(23), André G. Uitterlinden(22), Alan B. Zonderman(18), Najaf Amin(16), Stella Trompet(13), Jouke‐Jan Hottenga(13), H. Eka D. Suchiman(13), Cisca Wijmenga(13), Coen D.A. Stehouwer(12), Lude Franke(12), J. Wouter Jukema(12), Massimo Mangino(11), Anton J. M. de Craen(11), Carla Kallen(11), Marleen M. J. van Greevenbroek(11), Bastiaan T. Heijmans(11), Tōnu Esko(10)