Kai‐Jiong Xiao

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Chemistry · Physical Sciences

22h-index2.3kcitations63works4.32yr avg
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Research Topics

Advanced Synthetic Organic Chemistry(24), Chemical Synthesis and Analysis(22), Synthesis and Catalytic Reactions(14), Catalytic C–H Functionalization Methods(13), Asymmetric Hydrogenation and Catalysis(13)

Publications63 total

Nature-Inspired Continuous N-C Chain Elongation Enables Sustainable Peptide Synthesis
2026Open Access
Asymmetric Synthesis of KRAS G12C Inhibitor MK-1084 via a Crystallization-Induced Diastereomer Transformation (CIDT)
Organic Letters·2026
Nature-Inspired Continuous N-C Chain Elongation Enables Sustainable Peptide Synthesis
2025
Scalable Synthesis of a Dual TLR7/8 Agonist via Highly Selective <i>N</i> 2-Alkylation of 1 <i>H</i> -Pyrazolo[4,3- <i>d</i> ]pyrimidine
Organic Letters·2025
Scalable total synthesis of saxitoxin and related natural products
Nature·2025· 6 citedOpen Access
Leveraging Reactive Crystal Spherical Agglomeration to Enable a Scalable and Gelation-Free Manufacturing Process for Medium-Length Fatty Acid Sodium Salts
Crystal Growth & Design·2025
Biocatalytic Aerobic Oxidation for Large-Scale Production of <i>trans</i>-3-Hydroxy-<scp>l</scp>-Proline
Organic Process Research & Development·2025· 2 cited
Process Development toward a Key Fragment of the PCSK9 Inhibitor Enlicitide Decanoate
Organic Process Research & Development·2025· 2 cited
Total Synthesis of Enlicitide Decanoate
Journal of the American Chemical Society·2025· 28 cited
Scalable, Convergent Total Synthesis of (+)-Saxitoxin and Related Natural Products
2025· 2 citedOpen Access
Pilot-Scale Operation and Characterization of an Organolithium-Mediated Coupling Reaction in Flow to Form a Ketone Intermediate on the Route to Nemtabrutinib
Organic Process Research & Development·2024· 1 cited
Development of a Green and Sustainable Manufacturing Process for a Key Intermediate to Nemtabrutinib (MK-1026): Sequential Deprotonation–Lithiation as a Batch–Flow Process
Organic Process Research & Development·2024· 1 cited
Discovery of (4-Pyrazolyl)-2-aminopyrimidines as Potent and Selective Inhibitors of Cyclin-Dependent Kinase 2
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
Benzylic Photobromination for the Synthesis of Belzutifan: Elucidation of Reaction Mechanisms Using In Situ LED-NMR
The Journal of Organic Chemistry·2021· 28 cited
Abstract 4480: Preclinical characterization of potent and selective oral PD-L1 small-molecule antagonists
Experimental and Molecular Therapeutics·2019· 1 cited
Abstract 4480: Preclinical characterization of potent and selective oral PD-L1 small-molecule antagonists
Cancer Research·2019· 1 cited
Abstract 4483: Novel small-molecule antagonists of the PD-1/PD-L1 axis that mediate cell surface PD-L1 dimerization and internalization
Experimental and Molecular Therapeutics·2019· 1 cited
Abstract 4483: Novel small-molecule antagonists of the PD-1/PD-L1 axis that mediate cell surface PD-L1 dimerization and internalization
Cancer Research·2019· 3 cited
ChemInform Abstract: Kinetic Resolution of Benzylamines via Palladium(II)‐Catalyzed C—H Cross‐Coupling.
ChemInform·2016
Metal-Free Intermolecular Coupling of Arenes with Secondary Amides: Chemoselective Synthesis of Aromatic Ketimines and Ketones, and <i>N</i>-Deacylation of Secondary Amides
The Journal of Organic Chemistry·2016· 57 cited
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Frequent Co-authors

Pei‐Qiang Huang(21), Jin‐Quan Yu(12), Yinghong Huang(7), Ai‐E Wang(6), Ling Chu(6), Ru‐Yi Zhu(5), Lushi Tan(5), Liangxing Wu(5), Suhua Li(4), Jie‐Min Luo(4), Ke‐Yin Ye(4), David A. Thaisrivongs(4), Gao Shang(4), Qinghao Chen(4), Jingjun Yin(4), Peggy Scherle(4), Reid Huber(4), Gregory Hollis(4), Yu Wang(3), Yu Wang(3)