Alexandre Maréchal

Université de Sherbrooke — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index4.3kcitations46works4.12yr avg
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Research Topics

DNA Repair Mechanisms(32), CRISPR and Genetic Engineering(14), Cancer-related Molecular Pathways(7), Telomeres, Telomerase, and Senescence(7), Microtubule and mitosis dynamics(5)

Publications46 total

Single-stranded DNA-binding proteins at healthy and diseased telomeres
Trends in Biochemical Sciences·2026
Ubiquitination of the histone variant mH2A1.2 prevents toxic RAD18 accumulation at a subset of genomic loci upon replication stress
Molecular Cell·2025· 2 citedOpen Access
The function of MYC in base excision repair protects against RAS-induced senescence
Nucleic Acids Research·2025· 1 citedOpen Access
The single-stranded DNA–binding factor SUB1/PC4 alleviates replication stress at telomeres and is a vulnerability of ALT cancer cells
Proceedings of the National Academy of Sciences·2025· 7 citedOpen Access
Detection of γ-H2A.X for Rapid Assessment of Genotoxic Agent-induced Double-strand DNA Breaks by Immunofluorescence
Methods in molecular biology·2025· 1 cited
The Single-Stranded DNA-Binding Factor SUB1/PC4 Alleviates Replication Stress at Telomeres and is a Vulnerability of ALT Cancer Cells
2024Open Access
Heterozygous<i>RPA2</i>variant as a novel genetic cause of telomere biology disorders
Genes & Development·2024· 2 citedOpen Access
An E3 ubiquitin ligase localization screen uncovers DTX2 as a novel ADP-ribosylation-dependent regulator of DNA double-strand break repair
Journal of Biological Chemistry·2024· 15 citedOpen Access
SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability
PLoS Biology·2024· 9 citedOpen Access
Differential effects of pesticides on dioxin receptor signaling and p53 activation
Scientific Reports·2023· 2 citedOpen Access
The function of BCL11B in base excision repair contributes to its dual role as an oncogene and a haplo-insufficient tumor suppressor gene
Nucleic Acids Research·2023· 13 citedOpen Access
Chronic treatment with ATR and CHK1 inhibitors does not substantially increase the mutational burden of human cells
Mutation research. Fundamental and molecular mechanisms of mutagenesis·2023
The mutational impact of Illudin S on human cells
DNA repair·2022· 10 cited
The DNA repair function of BCL11A suppresses senescence and promotes continued proliferation of triple-negative breast cancer cells
NAR Cancer·2022· 12 citedOpen Access
The PRP19 Ubiquitin Ligase, Standing at the Cross-Roads of mRNA Processing and Genome Stability
Cancers·2022· 16 citedOpen Access
POGZ promotes homology‐directed DNA repair in an HP1‐dependent manner
EMBO Reports·2021· 31 citedOpen Access
POGZ modulates the DNA damage response in a HP1-dependent manner
2021Open Access
CUT Domains Stimulate Pol β Enzymatic Activities to Accelerate Completion of Base Excision Repair
Journal of Molecular Biology·2021· 11 cited
Human High-Density Lipoprotein Microtranscriptome is Unique and Suggests an Extended Role in Lipid Metabolism
Epigenomics·2019· 12 cited
Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication
International Journal of Molecular Sciences·2018· 19 citedOpen Access
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Frequent Co-authors

Billel Djerir(13), Lee Zou(8), Théo Morin(8), Normand Brisson(5), Steven Findlay(5), Alexandre Orthwein(5), Laurent Cappadocia(5), Jean-Christophe Dubois(5), Isabelle Marois(5), Lisa Casimir(5), John A. Heath(4), Vincent Luo(4), Martin Karam(4), Halil Bagci(4), Damien Grapton(4), Jean‐François Côté(4), Maïlyn Yates(4), Luc Gaudreau(4), Elise Vickridge(4), Camila Cristina Fraga Faraco(4)