Lianshan Zhang

Acadia Pharmaceuticals (United States) — United States

Neuroscience · Life Sciences

9h-index1.5kcitations13works0.02yr avg
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Research Topics

Regulation of Appetite and Obesity(6), Chemical Synthesis and Analysis(4), Biochemical Analysis and Sensing Techniques(4), Microbial Natural Products and Biosynthesis(2), Diabetes Treatment and Management(2)

Publications13 total

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents
Nature Medicine·2014· 609 citedOpen Access
Unimolecular Dual Incretins Maximize Metabolic Benefits in Rodents, Monkeys, and Humans
Science Translational Medicine·2013· 658 cited
Discovery and Optimization of β-MSH Derived Melanocortin-4 Selective Agonists
2010
pI-shifted Basal Insulin Analogs with High Selectivity for Insulin vs IGF-1 Receptor
2010
pI-shifted insulin analogs with extended in vivo time action and favorable receptor selectivity
Peptides·2007· 52 cited
Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold
Bioorganic & Medicinal Chemistry Letters·2005· 10 cited
Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human β-MSH(5–22) by dipeptidyl peptidase I and dipeptidyl peptidase IV
Peptides·2005· 7 cited
Discovery of a β-MSH-Derived MC-4R Selective Agonist
Journal of Medicinal Chemistry·2005· 17 citedOpen Access
Novel Approaches to the Synthesis of Cryptophycin and Related Depsipeptides
ChemInform·2003· 1 cited
Solid-phase synthesis of peptide–heterocycle hybrids containing a tripeptide-derived 6,6-fused bicyclic subunit
Tetrahedron Letters·2001· 15 cited
Single-Step Formation of Structurally Defined Bicyclic Peptides via S<sub>N</sub>Ar Cyclization
Organic Letters·2001· 12 cited
Solid-Phase Synthesis of C-Terminal Peptide Hydroxamic Acids
Journal of Combinatorial Chemistry·2001· 20 cited
A new ligation method for N-terminal tryptophan-containing peptides using the Pictet–Spengler reaction
Tetrahedron Letters·2000· 77 cited

Frequent Co-authors

Richard D. DiMarchi(7), David L. Smiley(6), John P. Mayer(6), Steven D. Kahl(5), Wayne D. Kohn(4), Hansen M. Hsiung(4), Mark L. Heiman(4), Liang Yan(4), David B. Flora(3), Patrick J. B. Edwards(3), Dennis P. Smith(3), Robert A. Gadski(3), JeAnne Hertel(3), Paul J. Emmerson(3), Saba Husain(3), Thomas P. O’Brien(3), Brian Finan(2), Tao Ma(2), Nickki Ottaway(2), Timo D. Müller(2)