Keith Gottesdiener

Medicine · Health Sciences

54h-index11.5kcitations156works0.02yr avg
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Research Topics

Inflammatory mediators and NSAID effects(24), Trypanosoma species research and implications(22), Regulation of Appetite and Obesity(18), Pharmacogenetics and Drug Metabolism(13), Diabetes Treatment and Management(13)

Publications155 total

Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment
UNC Libraries·2024Open Access
A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway
Skin Pharmacology and Physiology·2021· 30 citedOpen Access
Supplementary Material for: A Melanocortin-4 Receptor Agonist Induces Skin and Hair Pigmentation in Patients with Monogenic Mutations in the Leptin-Melanocortin Pathway
Figshare·2021Open Access
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency
Yearbook of pediatric endocrinology·2018· 11 cited
Evaluation of a melanocortin-4 receptor (MC4R) agonist (setmelanotide) in MC4R deficiency
Yearbook of pediatric endocrinology·2018· 5 cited
Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment
The Journal of Clinical Endocrinology & Metabolism·2018· 77 citedOpen Access
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency
Nature Medicine·2018· 294 cited
Efficacy and Safety of Relamorelin in Diabetics With Symptoms of Gastroparesis: A Randomized, Placebo-Controlled Study
Gastroenterology·2017· 149 citedOpen Access
Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency
Molecular Metabolism·2017· 287 citedOpen Access
Relamorelin in Patients with Diabetic Gastroparesis: Efficacy and Safety Results from a Phase 2B Randomized, Double-Blind, Placebo-Controlled, 12-Week Study (RM-131-009)
Gastroenterology·2017· 8 cited
Treatment for Early Onset and Extreme Obesity in Two POMC Deficient Patients: Successful Weight Loss with the Melanocortin-4 Receptor Agonist Setmelanotide
55th ESPE Meeting·2016
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist
New England Journal of Medicine·2016· 462 cited
Relamorelin Reduces Vomiting Frequency and Severity and Accelerates Gastric Emptying in Adults With Diabetic Gastroparesis
Gastroenterology·2016· 127 citedOpen Access
RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, is Being Therapeutically Evaluated in Patients with Deficiencies in the Leptin - Proopiomelanocortin (POMC) - MC4R Hypothalamic Pathway, Including Prader-Willi Syndrome (PWS)
54th ESPE Meeting (ESPE 2015)·2015
Relamorelin Relieves Constipation and Accelerates Colonic Transit in a Phase 2, Placebo-Controlled, Randomized Trial
Clinical Gastroenterology and Hepatology·2015· 48 cited
Inhibition of prostacyclin and thromboxane biosynthesis in healthy volunteers by single and multiple doses of acetaminophen and indomethacin
Clinical Pharmacology in Drug Development·2015· 8 cited
RM-493, a Melanocortin-4 Receptor (MC4R) Agonist, Increases Resting Energy Expenditure in Obese Individuals
The Journal of Clinical Endocrinology & Metabolism·2015· 172 citedOpen Access
Preclinical gastrointestinal prokinetic efficacy and endocrine effects of the ghrelin mimetic RM-131
Life Sciences·2014· 53 cited
929a A Phase 2, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of RM-131 in Patients with Diabetic Gastroparesis
Gastroenterology·2014· 23 citedOpen Access
Diary of hot flashes reported upon occurrence
Menopause The Journal of The North American Menopause Society·2014· 17 cited
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Frequent Co-authors

John A. Wagner(17), Kenneth C. Lasseter(8), Julie A. Stone(7), Gary Herman(6), Marian Iwamoto(6), Josée Côté(5), Lex H.T. Van der Ploeg(5), Larissa Wenning(5), Patrick Larson(4), Arthur Bergman(4), Bret J. Musser(4), Amelia S. Petry(4), Nancy Agrawal(4), Jeffrey Chodakewitz(3), Barry J. Gertz(3), Caroline Cilissen(3), Marina De Smet(3), Inge De Lepeleire(3), Kristien Van Dyck(3), H. Donald Burns(3)