Jens Halvard Grønlien

Abbott (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.2kcitations22works0.02yr avg
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Research Topics

Nicotinic Acetylcholine Receptors Study(19), Receptor Mechanisms and Signaling(18), Cholinesterase and Neurodegenerative Diseases(9), Ion channel regulation and function(5), Neuroscience and Neuropharmacology Research(2)

Publications22 total

In vitro pharmacological characterization of ABT-779, a novel positive allosteric modulator of α7 nAChRs
Biochemical Pharmacology·2011· 1 cited
Functional Characterization and High-Throughput Screening of Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors in IMR-32 Neuroblastoma Cells
Assay and Drug Development Technologies·2011· 9 cited
Importance of M2–M3 loop in governing properties of genistein at the α7 nicotinic acetylcholine receptor inferred from α7/5-HT3A chimera
European Journal of Pharmacology·2010· 24 cited
α3 and α7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells
Neurochemistry International·2010· 15 cited
In Vitro Pharmacological Characterization of a Novel Selective α7 Neuronal Nicotinic Acetylcholine Receptor Agonist ABT-107
Journal of Pharmacology and Experimental Therapeutics·2010· 50 cited
Syntheses and structure–activity relationship (SAR) studies of 2,5-diazabicyclo[2.2.1]heptanes as novel α7 neuronal nicotinic receptor (NNR) ligands
Bioorganic & Medicinal Chemistry Letters·2010· 11 citedOpen Access
Correction to “An Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor Possessing Cognition-Enhancing Properties in Vivo”
Journal of Pharmacology and Experimental Therapeutics·2009· 1 citedOpen Access
Structure–activity relationships of N-substituted ligands for the α7 nicotinic acetylcholine receptor
Bioorganic & Medicinal Chemistry Letters·2009· 5 citedOpen Access
Role of channel activation in cognitive enhancement mediated by α7 nicotinic acetylcholine receptors
British Journal of Pharmacology·2009· 60 citedOpen Access
In vitro pharmacological profile of a novel α4β2 positive allosteric modulator NS9283 (A-969933)
Biochemical Pharmacology·2009· 7 cited
α3* and α7* nAChR mediated Ca2+ transient generation in neuroblastoma IMR-32 cells
Biochemical Pharmacology·2009
Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists and Positive Allosteric Modulators Using the Parallel Oocyte Electrophysiology Test Station
Assay and Drug Development Technologies·2009· 25 cited
Octahydropyrrolo[3,4-<i>c</i>]pyrrole: A Diamine Scaffold for Construction of Either α4β2 or α7-Selective Nicotinic Acetylcholine Receptor (nAChR) Ligands. Substitutions that Switch Subtype Selectivity
Journal of Medicinal Chemistry·2009· 22 citedOpen Access
Stimulation of dopamine release by nicotinic acetylcholine receptor ligands in rat brain slices correlates with the profile of high, but not low, sensitivity α4β2 subunit combination
Biochemical Pharmacology·2009· 44 cited
Discovery of 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1<i>H</i>-pyrrol-1-yl)benzenesulfonamide (A-867744) as a Novel Positive Allosteric Modulator of the α7 Nicotinic Acetylcholine Receptor
Journal of Medicinal Chemistry·2009· 52 citedOpen Access
In Vitro Pharmacological Characterization of a Novel Allosteric Modulator of α7 Neuronal Acetylcholine Receptor, 4-(5-(4-Chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), Exhibiting Unique Pharmacological Profile
Journal of Pharmacology and Experimental Therapeutics·2009· 61 cited
Preclinical Characterization of A‐582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition‐Enhancing Properties
CNS Neuroscience & Therapeutics·2008· 81 citedOpen Access
Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties
CNS Neuroscience & Therapeutics·2008· 64 cited
α7 nicotinic acetylcholine receptor agonist properties of tilorone and related tricyclic analogues
British Journal of Pharmacology·2007· 35 citedOpen Access
Broad-Spectrum Efficacy across Cognitive Domains by α7 Nicotinic Acetylcholine Receptor Agonism Correlates with Activation of ERK1/2 and CREB Phosphorylation Pathways
Journal of Neuroscience·2007· 185 citedOpen Access
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Frequent Co-authors

Murali Gopalakrishnan(19), John Malysz(19), Hilde Ween(15), Clark A. Briggs(15), David J. Anderson(14), Kirsten Thorin‐Hagene(12), William H. Bunnelle(11), Monika Håkerud(9), Tino Dyhring(7), Dan Peters(7), Michael D. Meyer(6), Daniel B. Timmermann(5), Earl J. Gubbins(5), Kathy L. Kohlhaas(4), Philip K. Ahring(4), Gunnar Olsen(4), Peter Curzon(4), Jennifer M. Frost(4), Kennan C. Marsh(4), Richard J. Radek(4)