Rubén J. Boado

University of California, Los Angeles — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

62h-index11.7kcitations223works2.02yr avg
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Research Topics

RNA Interference and Gene Delivery(34), Lysosomal Storage Disorders Research(30), Virus-based gene therapy research(21), Monoclonal and Polyclonal Antibodies Research(21), Advanced biosensing and bioanalysis techniques(20)

Publications223 total

The legacy of William M. Pardridge (1947–2024) on the science and fields concerned with the physiology of the blood-brain barrier and the transport of drugs to the brain
Fluids and Barriers of the CNS·2025· 5 citedOpen Access
Impact of the Drug Act on Foreign Mothers Incarcerated in Arica
Feminist Criminology·2025
Brain delivery of biotherapeutics <i>via</i> receptor-mediated transcytosis across the blood–brain barrier
RSC Pharmaceutics·2025· 1 citedOpen Access
Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme AGT-194
Molecular Genetics and Metabolism·2023
Treatment of CLN1 disease with a blood-brain barrier penetrating lysosomal enzyme
Molecular Genetics and Metabolism Reports·2022· 5 citedOpen Access
IgG Fusion Proteins for Brain Delivery of Biologics via Blood–Brain Barrier Receptor-Mediated Transport
Pharmaceutics·2022· 26 citedOpen Access
Bi-functional IgG-lysosomal enzyme fusion proteins for brain drug delivery
Scientific Reports·2019· 28 citedOpen Access
A Brain Penetrating Bifunctional Erythropoietin-Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease
Molecular Pharmaceutics·2019· 3 citedOpen Access
P2‐165: HEMATOLOGIC SAFETY OF A BRAIN PENETRATING ERYTHROPOIETIN‐TRANSFERRIN RECEPTOR ANTIBODY FUSION PROTEIN IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
Alzheimer s & Dementia·2019Open Access
Plasma Pharmacokinetics of High-Affinity Transferrin Receptor Antibody-Erythropoietin Fusion Protein is a Function of Effector Attenuation in Mice
Molecular Pharmaceutics·2019· 21 citedOpen Access
Platform technology for treatment of the brain in lysosomal disorders: Application to Tay-Sachs disease
Molecular Genetics and Metabolism·2019
Platform technology for treatment of the brain in lysosomal diseases: Application to NCL1 Batten disease
Molecular Genetics and Metabolism·2019
Preclinical studies of a brain penetrating IgG Trojan horse-arylsulfatase fusion protein in the metachromatic leukodystrophy mouse
Molecular Genetics and Metabolism·2019· 6 cited
Platform technology for treatment of the brain in lysosomal disorders: Application to Niemann-Pick disease type A
Molecular Genetics and Metabolism·2019· 1 cited
Hematologic safety of chronic brain‐penetrating erythropoietin dosing in APP/PS1 mice
Alzheimer s & Dementia Translational Research & Clinical Interventions·2019· 19 citedOpen Access
Brain Penetrating Bifunctional Erythropoietin–Transferrin Receptor Antibody Fusion Protein for Alzheimer’s Disease
Molecular Pharmaceutics·2018· 55 cited
Blood-Brain Barrier Transport, Plasma Pharmacokinetics, and Neuropathology Following Chronic Treatment of the Rhesus Monkey with a Brain Penetrating Humanized Monoclonal Antibody Against the Human Transferrin Receptor
Molecular Pharmaceutics·2018· 63 cited
Neurocognitive and somatic stabilization in pediatric patients with severe Mucopolysaccharidosis Type I after 52 weeks of intravenous brain-penetrating insulin receptor antibody-iduronidase fusion protein (valanafusp alpha): an open label phase 1-2 trial
Orphanet Journal of Rare Diseases·2018· 137 citedOpen Access
P3‐057: THERAPEUTIC EFFECTS OF A BRAIN PENETRATING BISPECIFIC ERYTHROPOIETIN‐TRANSFERRIN RECEPTOR ANTIBODY FUSION PROTEIN IN THE APP/PS1 MOUSE MODEL OF ALZHEIMER'S DISEASE
Alzheimer s & Dementia·2018· 1 citedOpen Access
Plasma Pharmacokinetics of Valanafusp Alpha, a Human Insulin Receptor Antibody-Iduronidase Fusion Protein, in Patients with Mucopolysaccharidosis Type I
BioDrugs·2018· 48 cited
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Frequent Co-authors

William M. Pardridge(47), Yun Zhang(6), Chun‐Fang Xia(5), Eric Ka‐Wai Hui(5), Jeff Zhiqiang Lu(5), Jian Yi Li(4), Yun Zhang(4), Yufeng Zhang(3), Ningya Shi(3), Felix Schlachetzki(3), Yufeng Zhang(3), Qing-Hui Zhou(3), Chunni Zhu(2), Keith L. Black(2), Yun Zhang(2), Yufeng Zhang(2), Yuntao Wang(2), Rachita K. Sumbria(2), Christine R. Farrell(1), Marie Nagaya(1)