Thomas J. Abbruscato

Texas Tech University — United States

Neuroscience · Life Sciences

36h-index3.6kcitations113works4.12yr avg
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Research Topics

Neuropeptides and Animal Physiology(23), Neuroscience and Neuropharmacology Research(18), Barrier Structure and Function Studies(16), Drug Transport and Resistance Mechanisms(13), Cancer, Hypoxia, and Metabolism(11)

Publications113 total

Discovery of a pyridine-piperazine-based small molecule that enhances the activity of peptidase neurolysin
Journal of Pharmacology and Experimental Therapeutics·2026
Abstract WP353: Post-stroke infusion of metformin achieves pharmacological levels in the brain and ameliorates stroke outcomes in e-cigarette exposed mice
Stroke·2026
Dual use of combustible and electronic cigarettes progressively disrupts tight junctions and elevates oxidative stress, leading to compromised blood–brain barrier integrity
Toxicological Sciences·2025
Metformin’s protection against blood-brain barrier disruption and neuronal dysfunction under oxygen-glucose deprivation and tobacco smoke and e-vape chemical exposure
Fluids and Barriers of the CNS·2025· 1 citedOpen Access
Metformin's Permeability Across the Ischemic Brain and an Assessment of Blood-Brain Barrier Protection (Abstract ID: 190317)
Journal of Pharmacology and Experimental Therapeutics·2025
The Acute Impact of Propofol on Blood–Brain Barrier Integrity in Mice
Pharmaceutical Research·2024· 4 cited
Metformin ameliorates neuroinflammatory environment for neurons and astrocytes during in vitro and in vivo stroke and tobacco smoke chemical exposure: Role of Nrf2 activation
Redox Biology·2024· 24 citedOpen Access
Evaluation of systemic and brain pharmacokinetic parameters for repurposing metformin using intravenous bolus administration
Journal of Pharmacology and Experimental Therapeutics·2024· 9 citedOpen Access
Imidazole Bioisostere Activators of Endopeptidase Neurolysin with Enhanced Potency and Metabolic Stability
ACS Medicinal Chemistry Letters·2024· 3 citedOpen Access
Metformin Ameliorates Neuroinflammatory Environment for Neurons and Astrocytes During in Vitro and in Vivo Stroke and Tobacco Smoke Chemical Exposure: Role of Nrf2 Activation
SSRN Electronic Journal·2024Open Access
Discovery of the Next Generation of Non-peptidomimetic Neurolysin Activators with High Blood-Brain Barrier Permeability: a Pharmacokinetics Study in Healthy and Stroke Animals
Pharmaceutical Research·2023· 6 cited
Impact of in-utero electronic cigarette exposure on neonatal neuroinflammation, oxidative stress and mitochondrial function
Frontiers in Pharmacology·2023· 12 citedOpen Access
High brain-blood barrier permeability highlights a new class of neurolysin activators as promising candidates for stroke treatment: a pilot pharmacokinetic study in mice
Journal of Pharmacology and Experimental Therapeutics·2023Open Access
Permeability of Metformin across an In Vitro Blood–Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)
Pharmaceutics·2023· 42 citedOpen Access
Supplementary Figures 1 - 3 from Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
2023Open Access
Supplementary Methods from Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
2023Open Access
Supplementary Figure Legend from Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
2023Open Access
Supplementary Figures 4 - 8 from Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
2023Open Access
Supplementary Methods from Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
2023Open Access
Data from Arylsulfonamide KCN1 Inhibits <i>In Vivo</i> Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1α Interaction with Cofactors p300/CBP
2023Open Access
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Frequent Co-authors

Ali Ehsan Sifat(12), Bhuvaneshwar Vaidya(10), Heidi Villalba(10), Kaushik Shah(9), Vardan T. Karamyan(9), Saeideh Nozohouri(9), Tianzhi Yang(6), Sejal Sharma(6), Luca Cucullo(5), Karen E. Roder(5), Ulrich Bickel(5), Yang Li(5), Sabrina Rahman Archie(5), Thomas P. Davis(4), Jennifer R. Paulson(4), Alexander Mdzinarishvili(4), Mohammad A. Kaisar(3), Paul R. Lockman(3), Cornelis J. Van der Schyf(3), Jochen Klein(3)