Harold A. Chapman

University of British Columbia — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

93h-index31.5kcitations220works29.52yr avg
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Research Topics

Protease and Inhibitor Mechanisms(65), Neonatal Respiratory Health Research(49), Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis(38), Cell Adhesion Molecules Research(36), Blood Coagulation and Thrombosis Mechanisms(22)

Publications219 total

Unique molecular identifier-based single strand mitochondrial DNA sequencing for rare substitution mutations
2025Open Access
A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis
Journal of Clinical Investigation·2024· 59 citedOpen Access
BCL-2 Modulates IRE1α Activation to Attenuate Endoplasmic Reticulum Stress and Pulmonary Fibrosis
American Journal of Respiratory Cell and Molecular Biology·2023· 11 citedOpen Access
A fibroblast-dependent TGFβ1/sFRP2 noncanonical Wnt signaling axis underlies epithelial metaplasia in idiopathic pulmonary fibrosis
2023· 4 citedOpen Access
Data from Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
2023Open Access
Data from Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
2023Open Access
Supplementary Table 1, Figures 1-9, Methods from Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
2023Open Access
Supplementary Table 1, Figures 1-9, Methods from Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
2023Open Access
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
Nature·2022· 289 citedOpen Access
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
Nature Cell Biology·2021· 243 citedOpen Access
Nuclear IL-33 as a growth and survival agent within basal cells
Journal of Clinical Investigation·2021· 2 citedOpen Access
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis
2021· 1 citedOpen Access
Contextual cues from cancer cells govern cancer-associated fibroblast heterogeneity
Cell Reports·2021· 30 citedOpen Access
Blocking LOXL2 and TGFβ1 signalling induces collagen I turnover in precision-cut lung slices derived from patients with idiopathic pulmonary fibrosis
Thorax·2021· 48 citedOpen Access
Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function
UNC Libraries·2020· 6 citedOpen Access
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung
Nature Cell Biology·2020· 98 citedOpen Access
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
Nature Communications·2020· 421 citedOpen Access
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
Nature Communications·2020· 686 citedOpen Access
Human alveolar Type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells during alveolar repair
2020· 15 citedOpen Access
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
UNC Libraries·2020Open Access
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Frequent Co-authors

Guo‐Ping Shi(13), Ying Wei(10), Richard J. Riese(8), Alexis N. Brumwell(6), Hidde L. Ploegh(6), Jaymin J. Kathiriya(5), Jóse A. Villadangos(5), Edward E. Morrisey(4), Kevin K. Kim(3), Paul J. Wolters(3), Dean Sheppard(3), Jason R. Rock(3), Eric S. White(3), Michael A. Matthay(3), Galina K. Sukhova(3), David Waltz(3), Dieter Brömme(3), Darrell N. Kotton(3), John B. Hibbs(3), Rebecca A. R. Bryant(3)