Richard B. Lock

Cancer Institute of New South Wales — Australia

Medicine · Health Sciences

66h-index13.9kcitations629works4.92yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Acute Lymphoblastic Leukemia research(213), Neuroblastoma Research and Treatments(100), Acute Myeloid Leukemia Research(86), Cancer therapeutics and mechanisms(65), Chronic Myeloid Leukemia Treatments(57)

Publications629 total

P-glycoprotein as a chemotherapy resistance mechanism and biomarker of poor response in high-risk neuroblastoma
EJC Paediatric Oncology·2025· 1 citedOpen Access
Amx-883, a potent and selective degrader of BRD9 drives differentiation in acute myeloid leukaemia and shows synergistic efficacy in combination with venetoclax In Vivo and prevents the emergence of resistance to venetoclax in vitro.
Blood·2025Open Access
Abstract A002-PR011: Precision Diagnosis in High-Risk Pediatric Oncology through Integrated Whole Genome, Transcriptome, and Epigenome Profiling
Cancer Research·2025
Abstract 7041: The CLK/DYRK inhibitor SM09419 shows potent efficacy across a broad panel of pediatric preclinical xenograft models - A report from the Pediatric Preclinical In Vivo Testing Consortium (PIVOT)
Cancer Research·2025
Abstract IA017: Single mouse testing (SMT): An alternative approach to encompass clinical heterogeneity of pediatric cancers
Cancer Research·2025
Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine‐induced adverse effects in an acute lymphoblastic leukemia patient‐derived xenograft model
HemaSphere·2025· 2 citedOpen Access
Targeting osteoclasts for treatment of high-risk B-cell acute lymphoblastic leukemia
Blood Cancer Journal·2025· 1 citedOpen Access
Polyamine depletion limits progression of acute leukaemia
International Journal of Cancer·2025· 6 citedOpen Access
Immune‐deficient <scp>MISTRG</scp> mice support expansion of leukaemia‐initiating cells in xenograft models of paediatric acute myeloid leukaemia
British Journal of Haematology·2025· 2 citedOpen Access
Zero Childhood Cancer: a national approach to improving outcomes of Australian children with cancer through multiomic precision medicine
Pathology·2025· 1 cited
Targeting LMO2-induced autocrine FLT3 signaling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia
Leukemia·2025· 4 citedOpen Access
The CD123 antibody–drug conjugate pivekimab sunirine exerts profound activity in preclinical models of pediatric acute lymphoblastic leukemia
HemaSphere·2025· 4 citedOpen Access
Patient-Specific Circulating Tumor DNA for Monitoring Response to Menin Inhibitor Treatment in Preclinical Models of Infant Leukemia
Cancers·2024· 1 citedOpen Access
PU.1 eviction at lymphocyte-specific chromatin domains mediates glucocorticoid response in acute lymphoblastic leukemia
Nature Communications·2024· 6 citedOpen Access
The third generation AKR1C3-activated prodrug, ACHM-025, eradicates disease in preclinical models of aggressive T-cell acute lymphoblastic leukemia
Blood Cancer Journal·2024· 5 citedOpen Access
Lessons learned from 20 years of preclinical testing in pediatric cancers
Pharmacology & Therapeutics·2024· 11 citedOpen Access
269 (PB257): Development of a precision medicine platform for paediatric acute myeloid leukaemia
European Journal of Cancer·2024
TOPORS E3 ligase mediates resistance to hypomethylating agent cytotoxicity in acute myeloid leukemia cells
Nature Communications·2024· 14 citedOpen Access
Targeting LMO2-induced autocrine FLT3 signalling to overcome chemoresistance in early T-cell precursor acute lymphoblastic leukemia
2024Open Access
3049 – TARGETING BONE MARROW MICROENVIRONMENT FOR TREATMENT OF HIGH-RISK B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
Experimental Hematology·2024
page 1 of 32Next →

Frequent Co-authors

Malcolm A. Smith(19), Peter J. Houghton(17), C. Patrick Reynolds(17), John M. Maris(15), Christopher L. Morton(14), Richard Görlick(14), E. Anders Kolb(14), Hernán Carol(14), Stephen T. Keir(13), Catherine A. Billups(8), Jianrong Wu(7), Min H. Kang(7), Glenn M. Marshall(6), John E. Pimanda(4), Michelle Haber(4), Mayamin Tajbakhsh(4), Ricky W. Johnstone(4), Raushan T. Kurmasheva(4), Barbara Szymanska(4), Joshua Courtright(3)