Deborah A. Flusberg

Computer Science · Physical Sciences

9h-index917citations19works0.02yr avg
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Research Topics

Computational Drug Discovery Methods(5), RNA Interference and Gene Delivery(5), Cell death mechanisms and regulation(4), CAR-T cell therapy research(3), Microtubule and mitosis dynamics(2)

Publications19 total

Identifying an optimal dose range for clinical development of BT7480 using a fit-for-purpose quantitative system pharmacology (QSP) modeling
2026Open Access
High‐Throughput CRISPR/Cas9 Mediated Gene Editing of Primary Human T Cells in a Microfluidic Device for Cellular Therapy Manufacturing (Adv. Mater. Technol. 17/2023)
Advanced Materials Technologies·2023Open Access
A Quantitative Systems Pharmacology Model Describing the Cellular Kinetic‐Pharmacodynamic Relationship for a Live Biotherapeutic Product to Support Microbiome Drug Development
Clinical Pharmacology & Therapeutics·2023· 5 citedOpen Access
High‐Throughput CRISPR/Cas9 Mediated Gene Editing of Primary Human T Cells in a Microfluidic Device for Cellular Therapy Manufacturing
Advanced Materials Technologies·2023· 9 cited
Recurrent Urinary Tract Infection: A Mystery in Search of Better Model Systems
Frontiers in Cellular and Infection Microbiology·2021· 124 citedOpen Access
High-throughput continuous-flow microfluidic electroporation of mRNA into primary human T cells for applications in cellular therapy manufacturing
Scientific Reports·2020· 70 citedOpen Access
The ghost of cells past, Part 4
Critical Care Medicine·2020
Identification of G-Quadruplex-Binding Inhibitors of Myc Expression through Affinity Selection–Mass Spectrometry
SLAS DISCOVERY·2018· 28 citedOpen Access
Surviving apoptosis: life–death signaling in single cells
Trends in Cell Biology·2015· 139 citedOpen Access
Modulating cell-to-cell variability and sensitivity to death ligands by co-drugging
Physical Biology·2013· 20 citedOpen Access
Cells surviving fractional killing by TRAIL exhibit transient but sustainable resistance and inflammatory phenotypes
Molecular Biology of the Cell·2013· 94 citedOpen Access
Real-time imaging of the dynamics of death receptors and therapeutics that overcome TRAIL resistance in tumors
Oncogene·2012· 49 citedOpen Access
MEASURING AND MODELING LIFE‐DEATH DECISIONS IN SINGLE CELLS
The FASEB Journal·2012· 2 cited
Abstract SY17-03: Inferring cell death networks from biochemical data
Cancer Research·2011
Abstract ES6-2: Cell to Cell Variability in the Responses of Tumor Cells to Death Ligands and Other Anti-Cancer Drugs
Cancer Research·2010
Abstract SY19-01: Cell to cell variability in the responses of tumor cells to death ligands
Cancer Research·2010
Effects of SLx-2119, a novel small molecule inhibitor of Rho-associated kinase ROCK (ROK), on growth of human tumor xenografts in nude mice
Cancer Research·2005· 9 cited
Cooperative Control of Akt Phosphorylation, bcl-2 Expression, and Apoptosis by Cytoskeletal Microfilaments and Microtubules in Capillary Endothelial Cells
Molecular Biology of the Cell·2001· 98 cited
A functional p53-responsive intronic promoter is contained within the human<i>mdm2</i>gene
Nucleic Acids Research·1995· 270 citedOpen Access

Frequent Co-authors

Peter K. Sorger(7), Sabrina L. Spencer(5), Suzanne Gaudet(4), Charles Lissandrello(3), José A. L. Santos(3), Peter Hsi(3), Michaela Welch(3), Ernest S. Kim(3), Nerses J. Haroutunian(3), Jonathan Coppeta(3), Jenna L. Balestrini(3), Vishal Tandon(3), Stacey Markovic(2), Marissa Renardy(2), Arie Zauberman(1), Ygal Haupt(1), Yaacov Barak(1), Moshe Oren(1), Benjamin Murray(1), Carlos Flores(1)