Pawel J. Sikorski

University of Warsaw — Poland

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index1.1kcitations39works9.02yr avg
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Research Topics

RNA and protein synthesis mechanisms(27), RNA Research and Splicing(21), RNA modifications and cancer(20), Click Chemistry and Applications(7), Cancer-related gene regulation(5)

Publications39 total

Effective recognition of double-stranded RNA does not require activation of cellular inflammation
Science Advances·2025· 4 citedOpen Access
Expanding the Available RNA Labeling Toolbox With CutA Nucleotidyltransferase for Efficient Transcript Labeling with Purine and Pyrimidine Nucleotide Analogs
ChemBioChem·2024· 3 citedOpen Access
Effective recognition of double-stranded RNA does not require activation of cellular inflammation
2024· 1 citedOpen Access
Trinucleotide mRNA Cap Analogue <i>N</i>6-Benzylated at the Site of Posttranscriptional <sup>m6</sup>A<sub>m</sub> Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo
Journal of the American Chemical Society·2024· 28 citedOpen Access
Trinucleotide mRNA cap analog N6-benzylated at the site of posttranscriptional <sup>m6</sup> Am mark facilitates mRNA purification and confers superior translational properties in vitro and in vivo
2023Open Access
Synthesis and Evaluation of Diguanosine Cap Analogs Modified at the C8-Position by Suzuki–Miyaura Cross-Coupling: Discovery of 7-Methylguanosine-Based Molecular Rotors
The Journal of Organic Chemistry·2023· 5 citedOpen Access
2′- <i>O</i> -Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion
Nucleic Acids Research·2022· 77 citedOpen Access
2’- <i>O</i> -methylation of the second transcribed nucleotide within mRNA 5’ cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion
2022Open Access
Novel N7-Arylmethyl Substituted Dinucleotide mRNA 5′ cap Analogs: Synthesis and Evaluation as Modulators of Translation
Pharmaceutics·2021· 26 citedOpen Access
Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and <i>in vivo</i> translation
Nucleic Acids Research·2021· 20 citedOpen Access
RNA Ligation for Mono and Dually Labeled RNAs
Chemistry - A European Journal·2021· 8 cited
Evaluation of carboxyfluorescein-labeled 7-methylguanine nucleotides as probes for studying cap-binding proteins by fluorescence anisotropy
Scientific Reports·2021· 10 citedOpen Access
Tricks and threats of RNA viruses – towards understanding the fate of viral RNA
RNA Biology·2021· 38 citedOpen Access
Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect
ACS Chemical Biology·2021· 29 citedOpen Access
Cellular delivery of dinucleotides by conjugation with small molecules: targeting translation initiation for anticancer applications
Chemical Science·2021· 12 citedOpen Access
Phosphodiester modifications in mRNA poly(A) tail prevent deadenylation without compromising protein expression
RNA·2020· 60 citedOpen Access
Functional and LC-MS/MS analysis of <i>in vitro</i> transcribed mRNAs carrying phosphorothioate or boranophosphate moieties reveal polyA tail modifications that prevent deadenylation without compromising protein expression
2020· 1 citedOpen Access
Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation
Bioorganic & Medicinal Chemistry·2020· 14 citedOpen Access
The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5′ cap modulates protein expression in living cells
Nucleic Acids Research·2020· 140 citedOpen Access
The identity and methylation status of the first transcribed nucleotide in eukaryotic mRNA 5’ cap modulates protein expression in living cells
2019· 7 citedOpen Access
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Frequent Co-authors

Joanna Kowalska(28), Jacek Jemielity(28), Marcin Warmiński(20), Renata Kasprzyk(8), Dorota Kubacka(7), Karolina Drążkowska(6), Adam Mamot(6), Natalia Baran(5), Łukasz Markiewicz(5), Joanna Zuberek(5), Dominika Nowis(4), Rafał Tomecki(4), Joanna Kufel(4), Elżbieta Nowak(4), Marcin Nowotny(4), Dominik Cysewski(4), Anaïs Depaix(4), Dominika Strzelecka(4), Mirosław Śmietański(4), Marek R. Baranowski(4)