David C. Nickle

Merck & Co., Inc., Rahway, NJ, USA (United States) — United States

Immunology and Microbiology · Life Sciences

59h-index14.3kcitations193works1.22yr avg
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Research Topics

HIV Research and Treatment(48), Chronic Obstructive Pulmonary Disease (COPD) Research(44), Asthma and respiratory diseases(34), HIV/AIDS drug development and treatment(24), Neonatal Respiratory Health Research(21)

Publications178 total

COPD susceptibility gene HHIP regulates repair genes in airway epithelial cells and repair within the epithelial-mesenchymal trophic unit
American Journal of Physiology-Lung Cellular and Molecular Physiology·2025Open Access
Phenotypic heterogeneity defines B cell responses to repeated SARS-CoV-2 exposures through vaccination and infection
Cell Reports·2025· 3 citedOpen Access
Improved Annotation of Asthma Gene Variants with Cell Type Deconvolution of Nasal and Lung Expression Quantitative Trait Loci
American Journal of Respiratory Cell and Molecular Biology·2025· 2 citedOpen Access
Predictive biomarkers of response to the IRAK4/FLT3 inhibitor emavusertib in hematological malignancies.
Journal of Clinical Oncology·2024· 2 cited
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Nature Genetics·2024Open Access
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
Digital Commons@Becker (Washington University School of Medicine)·2024Open Access
688 Transcriptome analyses in patients with myeloid malignances treated with the IRAK4 inhibitor emavusertib
Regular and Young Investigator Award Abstracts·2023Open Access
Age-associated differences in the human lung extracellular matrix
American Journal of Physiology-Lung Cellular and Molecular Physiology·2023· 44 citedOpen Access
Age-associated Differences in the Human Lung Extracellular Matrix _ Supplementary materials
Figshare·2023Open Access
Age-associated Differences in the Human Lung Extracellular Matrix
2022· 5 citedOpen Access
Age-Associated Changes in the Human Lung Extracellular Matrix
2022· 1 cited
Genetic Associations and Architecture of Asthma-COPD Overlap
CHEST Journal·2022· 41 citedOpen Access
Supplementary materials
University of Groningen research database (University of Groningen / Centre for Information Technology)·2022Open Access
Supplementary file 1.xlsx
University of Groningen research database (University of Groningen / Centre for Information Technology)·2022Open Access
Supplementary materials for the manuscript "Age-associated Differences in Human Lung Extracellular Matrix"
University of Groningen research database (University of Groningen / Centre for Information Technology)·2022Open Access
Late Breaking Abstract - Evidence of target engagement and pathway modulation: biomarker analysis of the phase 1b inhaled seralutinib study
2021
Prioritization of candidate causal genes for asthma in susceptibility loci derived from UK Biobank
Communications Biology·2021· 162 citedOpen Access
Lung Transcriptomics Provide Insights into the Sex Differences in Chronic Obstructive Pulmonary Disease
2021Open Access
The Genetics of HIV-1
Princeton University Press eBooks·2021
Detection of respiratory syncytial virus defective genomes in nasal secretions is associated with distinct clinical outcomes
Nature Microbiology·2021· 66 citedOpen Access
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Frequent Co-authors

James I. Mullins(23), Yohan Bossé(14), Don D. Sin(13), Gerald H. Learn(10), Ma’en Obeidat(10), Maarten van den Berge(9), Mark A. Jensen(8), Daniel Shriner(8), Ke Hao(7), Wim Timens(7), David Heckerman(6), Corry‐Anke Brandsma(6), Louise V. Wain(6), Christine Rousseau(5), Nick Shrine(5), Ian Sayers(5), María Soler Artigas(5), Peter D. Paré(5), Dirkje S. Postma(5), Michel Laviolette(5)