Lorie Marchitto

University of Pennsylvania — United States

Immunology and Microbiology · Life Sciences

12h-index621citations50works4.22yr avg
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Research Topics

HIV Research and Treatment(21), SARS-CoV-2 and COVID-19 Research(21), Immune Cell Function and Interaction(15), COVID-19 Clinical Research Studies(12), T-cell and B-cell Immunology(7)

Publications50 total

Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV V2 apex broadly neutralizing antibody development.
PubMed·2026
Shared Maturation Pathways of HIV-1 Envelope-reactive V3-glycan bnAb Lineages in Human and Rhesus Macaque
2026Open Access
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
Nature Communications·2025· 1 citedOpen Access
Consistent Induction of Broadly Neutralizing HIV Antibodies by a Novel Two-Step Mechanism Informs Immunogen Design
2025· 1 citedOpen Access
Env-antibody coevolution identifies B cell priming as the principal bottleneck to HIV-1 V2 apex broadly neutralizing antibody development
2025· 8 citedOpen Access
Safety, pharmacokinetics, and biological activity of CD4-mimetic BNM-III-170 in SHIV-infected rhesus macaques
Journal of Virology·2025· 1 citedOpen Access
8.2 – 00072 Early intervention with an indoline CD4-mimetic compound that sensitizes HIV-1-infected cells to ADCC favors post-treatment HIV control in humanized mice
Journal of Virus Eradication·2024Open Access
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
mBio·2024· 9 citedOpen Access
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
Journal of Virology·2024· 8 citedOpen Access
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in the presence of CD4-mimetics
Journal of Virology·2024· 10 citedOpen Access
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC
2024· 3 citedOpen Access
NTB-A and 2B4 Natural Killer Cell Receptors Modulate the Capacity of a Cocktail of Non-Neutralizing Antibodies and a Small CD4-Mimetic to Eliminate HIV-1-Infected Cells by Antibody-Dependent Cellular Cytotoxicity
Viruses·2024· 1 citedOpen Access
Impact of Prolonged SARS-CoV-2 Dosing Interval in Hemodialysis Patients
Kidney International Reports·2024· 1 citedOpen Access
The combination of three CD4-induced antibodies targeting highly conserved Env regions with a small CD4-mimetic achieves potent ADCC activity
2024· 4 citedOpen Access
Three families of CD4-induced antibodies are associated with the capacity of plasma from people living with HIV to mediate ADCC in presence of CD4-mimetics
2024· 3 citedOpen Access
Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity
Nature Communications·2024· 14 citedOpen Access
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies
2024· 7 citedOpen Access
Gaining Biological Insights through Supervised Data Visualization
2023· 2 citedOpen Access
NOX2 deficiency enhances priming and activation of the NLRP3 inflammasome
Journal of Allergy and Clinical Immunology·2023· 14 cited
Humoral Responses Elicited by SARS-CoV-2 mRNA Vaccine in People Living with HIV
Viruses·2023· 8 citedOpen Access
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Frequent Co-authors

Halima Medjahed(32), Andrés Finzi(31), Jonathan Richard(28), Catherine Bourassa(27), Guillaume Beaudoin-Bussières(23), Mehdi Benlarbi(22), Debashree Chatterjee(20), Gabrielle Gendron‐Lepage(20), Daniel E. Kaufmann(20), Shilei Ding(19), Jérémie Prévost(18), Alexandra Tauzin(17), Guillaume Goyette(17), Annemarie Laumaea(14), Valérie Martel‐Laferrière(13), Cécile Tremblay(13), Shang Yu Gong(12), Dani Vézina(11), Gérémy Sannier(11), Laurie Gokool(11)