Diane Kepka‐Lenhart

University of Pittsburgh — United States

Medicine · Health Sciences

20h-index2.9kcitations26works0.02yr avg
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Research Topics

Nitric Oxide and Endothelin Effects(14), Amino Acid Enzymes and Metabolism(6), Immune Response and Inflammation(4), Metabolism and Genetic Disorders(4), Adenosine and Purinergic Signaling(3)

Publications26 total

Shaping the Murine Macrophage Phenotype: IL-4 and Cyclic AMP Synergistically Activate the Arginase I Promoter
The Journal of Immunology·2013· 66 citedOpen Access
Microenvironments in Tuberculous Granulomas Are Delineated by Distinct Populations of Macrophage Subsets and Expression of Nitric Oxide Synthase and Arginase Isoforms
The Journal of Immunology·2013· 345 citedOpen Access
Selective Endothelial Overexpression of Arginase II Induces Endothelial Dysfunction and Hypertension and Enhances Atherosclerosis in Mice
PLoS ONE·2012· 35 citedOpen Access
Arginase-2 Mediates Diabetic Renal Injury
Diabetes·2011· 84 citedOpen Access
Adenosine promotes alternative macrophage activation <i>via</i> A2A and A2B receptors
The FASEB Journal·2011· 373 citedOpen Access
LXRα Regulates Macrophage Arginase 1 Through PU.1 and Interferon Regulatory Factor 8
Circulation Research·2011· 91 citedOpen Access
Arginase Activities and Global Arginine Bioavailability in Wild-Type and ApoE-Deficient Mice: Responses to High Fat and High Cholesterol Diets
PLoS ONE·2010· 33 citedOpen Access
Determination of Mammalian Arginase Activity
Methods in enzymology on CD-ROM/Methods in enzymology·2008· 31 cited
Cell- and Isoform-Specific Increases in Arginase Expression in Acute Silica-Induced Pulmonary Inflammation
Journal of Toxicology and Environmental Health·2007· 13 citedOpen Access
Synergistic induction of arginase I transcription in macrophage cells
The FASEB Journal·2007
Systemic changes in arginase and arginine metabolism in a model of atherosclerosis: a comparison of apoE−/− and C57 mice
The FASEB Journal·2007· 2 cited
Inhibition of phosphodiesterase 4 amplifies cytokine-dependent induction of arginase in macrophages
American Journal of Physiology-Lung Cellular and Molecular Physiology·2005· 51 cited
Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPβ
Gene·2005· 190 cited
Hydroxyurea and Arginine Therapy: Impact on Nitric Oxide Production in Sickle Cell Disease
Journal of Pediatric Hematology/Oncology·2003· 102 cited
Arginine Therapy
American Journal of Respiratory and Critical Care Medicine·2003· 324 cited
Hormonal induction of hepatic mitochondrial ornithine/citrulline transporter mRNA
Biochemical and Biophysical Research Communications·2002· 23 cited
Regulatory role of arginase I and II in nitric oxide, polyamine, and proline syntheses in endothelial cells
American Journal of Physiology-Endocrinology and Metabolism·2001· 385 cited
Arginase I: a limiting factor for nitric oxide and polyamine synthesis by activated macrophages?
American Journal of Physiology-Regulatory, Integrative and Comparative Physiology·2000· 99 cited
Salicylate-enhanced activation of transcription factors induced by interferon-γ
Biochemical Journal·1999· 18 citedOpen Access
Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells
American Journal of Physiology-Endocrinology and Metabolism·1998· 250 cited
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Frequent Co-authors

Sidney M. Morris(25), Mirjana Poljakovic(5), Li-Chun Chen(3), Aaron Erdely(3), Sanjay Mistry(2), Guoyao Wu(2), Claudia R. Morris(2), Jane van Warmerdam(2), Lorenzo Machado(2), Frans A. Kuypers(2), Elliott Vichinsky(2), Harish Shandilya(2), Rebecca Chapman(2), Tracy Hulderman(2), Petia P. Simeonova(2), Hui Li(1), Cynthia J. Meininger(1), James Hawker(1), Tony E. Haynes(1), Balázs Csóka(1)