Jason A. Iskarpatyoti

Duke Medical Center — United States

Medicine · Health Sciences

10h-index1.4kcitations16works0.02yr avg
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Research Topics

Viral gastroenteritis research and epidemiology(7), Virus-based gene therapy research(4), Ion Channels and Receptors(2), Mast cells and histamine(2), Animal Virus Infections Studies(2)

Publications16 total

Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice
UNC Libraries·2025Open Access
Platelet-mediated activation of perivascular mast cells triggers progression of sepsis to septic shock in mice
Nature Communications·2025Open Access
267 Inhibition of Orai1 with ELD607 is immunomodulatory and reduces chronic lung disease in cystic fibrosis ferrets
Journal of Cystic Fibrosis·2024
The Orai1 Antagonist ELD607 Safely Reduces Lung Inflammation in G551D Cystic Fibrosis Ferrets
2024
Specific Inhibition of Orai1-mediated Calcium Signalling Resolves Inflammation and Clears Bacteria in an Acute Respiratory Distress Syndrome Model
American Journal of Respiratory and Critical Care Medicine·2023· 14 citedOpen Access
Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter
Cell Reports·2022· 19 citedOpen Access
Mast cell regranulation involves a metabolic switch promoted by the interaction between mTORC1 and a glucose-6-phosphate transporter
2021Open Access
Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response
Pediatric Research·2018· 28 citedOpen Access
Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease
Science·2017· 447 citedOpen Access
Engineering Recombinant Reoviruses To Display gp41 Membrane-Proximal External-Region Epitopes from HIV-1
mSphere·2016· 5 citedOpen Access
Proteomic Analysis of Mitochondrial-Associated ER Membranes (MAM) during RNA Virus Infection Reveals Dynamic Changes in Protein and Organelle Trafficking
PLoS ONE·2015· 121 citedOpen Access
Prevention and cure of rotavirus infection via TLR5/NLRC4–mediated production of IL-22 and IL-18
Science·2014· 221 citedOpen Access
Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates
Nature·2014· 552 citedOpen Access
A plasmid-based reverse genetics system for mammalian orthoreoviruses driven by a plasmid-encoded T7 RNA polymerase
Journal of Virological Methods·2013· 17 cited
Serotype-specific differences in inhibition of reovirus infectivity by human-milk glycans are determined by viral attachment protein σ1
Virology·2012· 11 cited
A rapid, automated approach for quantitation of rotavirus and reovirus infectivity
Journal of Virological Methods·2012· 13 cited

Frequent Co-authors

Terence S. Dermody(8), Mine R. Ikizler(5), Andrea J. Pruijssers(4), Soman N. Abraham(4), Mathew Abraham(3), J. Denise Wetzel(3), Jennifer Stencel-Baerenwald(2), Karl W. Boehme(2), Jianling Shi(2), Yuxuan Miao(2), Maria F. Sassano(2), Robert Tarran(2), E. Ashley Morse(2), Nikhat Contractor(2), Alan A. Schmalstig(2), D. Glawe(2), Shohreh Fakhari(2), Hae Woong Choi(2), Joo Hwan Noh(2), Xiaoyi Zhu(2)