André White

Framingham State University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

24h-index3.2kcitations49works5.02yr avg
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Research Topics

Bacterial Genetics and Biotechnology(6), Toxin Mechanisms and Immunotoxins(5), Protein Degradation and Inhibitors(5), Synthesis and biological activity(4), DNA and Nucleic Acid Chemistry(4)

Publications49 total

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity
Nature·2025· 10 citedOpen Access
Discovery of VNRX-9945, a Potent, Broadly Active Capsid Assembly Modulator as a Clinical Candidate for the Treatment of Chronic Hepatitis B Virus Infection
ACS Medicinal Chemistry Letters·2025Open Access
S298: CS585 IS A FIRST-IN-CLASS COMPOUND TARGETING THE IP RECEPTOR FOR PREVENTION OF THROMBOSIS WITHOUT INCREASED RISK OF BLEEDING
HemaSphere·2022Open Access
The eptinezumab:CGRP complex structure – the role of conformational changes in binding stabilization
Bioengineered·2021· 7 citedOpen Access
Eptinezumab:CGRP Complex Structure and Characterization of the Ligand Binding Interface (1477)
Neurology·2021
Checkpoint inhibition through small molecule-induced internalization of programmed death-ligand 1
Nature Communications·2021· 130 citedOpen Access
Antibody-mediated inhibition of GDF15–GFRAL activity reverses cancer cachexia in mice
Nature Medicine·2020· 276 cited
Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine
Journal of Medicinal Chemistry·2018· 51 citedOpen Access
Erratum: Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Nature·2017· 10 citedOpen Access
Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15
Nature·2017· 590 cited
Structure Determination of <i>Mycobacterium tuberculosis</i> Serine Protease Hip1 (Rv2224c)
Biochemistry·2017· 13 citedOpen Access
RVX-297- a novel BD2 selective inhibitor of BET bromodomains
Biochemical and Biophysical Research Communications·2016· 54 cited
Discovery of a new chemical series of BRD4(1) inhibitors using protein-ligand docking and structure-guided design
Bioorganic & Medicinal Chemistry Letters·2015· 24 citedOpen Access
RVX-208, an Inducer of ApoA-I in Humans, Is a BET Bromodomain Antagonist
PLoS ONE·2013· 198 citedOpen Access
Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas
2011
A General and Special Catalyst for Suzuki–Miyaura Coupling Processes
Angewandte Chemie·2010· 56 cited
A General and Special Catalyst for Suzuki–Miyaura Coupling Processes
Angewandte Chemie International Edition·2010· 190 citedOpen Access
Chiral Biphosphorous Ligands for Rhodium-Catalyzed AsymmetricHydrogenation
Synfacts·2010
Novel and Efficient Chiral Bisphosphorus Ligands for Rhodium-Catalyzed Asymmetric Hydrogenation
Organic Letters·2010· 88 cited
Corrigendum to “Discovery, SAR and X-ray structure of 1H-benzimidazole-5-carboxylic acid cyclohexyl-methyl-amides as inhibitors of inducible T-cell kinase (Itk)” [Bioorg. Med. Chem. Lett. 18 (2008) 5545–5549]
Bioorganic & Medicinal Chemistry Letters·2009· 3 cited
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Frequent Co-authors

Dagmar Ringe(11), L. Damodharan(7), R.K. Suto(7), David R. Rose(6), Stephen G. Withers(5), Andrea Olland(4), Kevin G. McLure(4), Olesya A. Kharenko(4), Henrik C. Hansen(4), Peter R. Young(4), Wenjun Tang(4), Andrew G. Capacci(4), Jolaine Savoie(4), Sonia Rodrı́guez(4), Bo Qu(4), Nizar Haddad(4), Nathan K. Yee(4), Chris H. Senanayake(4), Dedreia Tull(4), John R. Murphy(4)