Pavel Moudrý

University Hospital Olomouc — Czech Republic

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index2.5kcitations23works5.72yr avg
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Research Topics

DNA Repair Mechanisms(12), Cancer-related Molecular Pathways(5), PARP inhibition in cancer therapy(4), CRISPR and Genetic Engineering(3), Ubiquitin and proteasome pathways(3)

Publications23 total

The need for speed: drivers and consequences of accelerated replication forks
Communications Biology·2025· 1 citedOpen Access
Quantitative AI-based DNA fiber workflow to study replication stress
2025· 1 citedOpen Access
DNA polymerase α-primase facilitates PARP inhibitor-induced fork acceleration and protects BRCA1-deficient cells against ssDNA gaps
Nature Communications·2024· 15 citedOpen Access
Emetine blocks DNA replication via proteosynthesis inhibition not by targeting Okazaki fragments
Life Science Alliance·2022· 12 citedOpen Access
A drug repurposing strategy for overcoming human multiple myeloma resistance to standard-of-care treatment
Cell Death and Disease·2022· 16 citedOpen Access
RNA-interference screen for p53 regulators unveils a role of WDR75 in ribosome biogenesis
Cell Death and Differentiation·2021· 29 citedOpen Access
Impaired ribosome biogenesis: mechanisms and relevance to cancer and aging
Aging·2019· 219 citedOpen Access
Abstract 455: Cellular response to oxaliplatin treatment shows altered DNA damage, nucleolar and ribosomal stresses as main altered pathways
Cancer Research·2018
High speed of fork progression induces DNA replication stress and genomic instability
Nature·2018· 513 cited
Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4
Nature·2017· 760 cited
Perturbation of RNA Polymerase I transcription machinery by ablation of HEATR1 triggers the RPL5/RPL11-MDM2-p53 ribosome biogenesis stress checkpoint pathway in human cells
Cell Cycle·2017· 44 citedOpen Access
Proteomic profiling reveals DNA damage, nucleolar and ribosomal stress are the main responses to oxaliplatin treatment in cancer cells
Journal of Proteomics·2017· 39 cited
Tumors overexpressing RNF168 show altered DNA repair and responses to genotoxic treatments, genomic instability and resistance to proteotoxic stress
Oncogene·2016· 53 cited
TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity
The Journal of Cell Biology·2016· 85 citedOpen Access
Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity
Oncotarget·2015· 20 citedOpen Access
Postranslational modifications in DNA damage response
2012
Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage
Cell Cycle·2012· 122 citedOpen Access
Autocrine VEGF-VEGFR2—Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
The Journal of Cell Biology·2012· 26 cited
Autocrine VEGF–VEGFR2–Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth
The Journal of Experimental Medicine·2012· 394 citedOpen Access
Nucleoporin NUP153 guards genome integrity by promoting nuclear import of 53BP1
Cell Death and Differentiation·2011· 74 citedOpen Access
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Frequent Co-authors

Jiří Bártek(12), Jiřina Bártková(6), Jiří Lukáš(6), Martin Mistrík(5), Zdeněk Hodný(5), Katarína Chromá(5), Jiří Bártek(4), Zdeněk Škrott(3), Ján Gurský(3), Tomáš Oždian(3), Zsofia Turi(3), Jana Václavková(3), Petr Džubák(3), Marián Hajdúch(3), Robert Strauss(3), Zuzana Machacova(3), Dávid Lukáč(3), Apolinar Maya‐Mendoza(2), Petra Hamerlik(2), Justin D. Lathia(2)