Ruben D. Carrasco

Harvard University — United States

Medicine · Health Sciences

39h-index8.1kcitations238works2.52yr avg
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Research Topics

Multiple Myeloma Research and Treatments(76), Chronic Lymphocytic Leukemia Research(65), Cancer Mechanisms and Therapy(28), Ubiquitin and proteasome pathways(27), Protein Degradation and Inhibitors(22)

Publications237 total

CD47 blockade-driven necroptosis complements BCL-2 inhibition-driven apoptosis in lymphoid malignancies
Journal of Hematology & Oncology·2026Open Access
Supplementary Tables from <i>In Vivo</i> Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities
2025Open Access
Supplementary Figures from <i>In Vivo</i> Modeling of CLL Transformation to Richter Syndrome Reveals Convergent Evolutionary Paths and Therapeutic Vulnerabilities
2025Open Access
Bone marrow spatial architecture predicts response duration in smoldering multiple myeloma patients receiving checkpoint inhibitor therapy
Blood·2025
Murine modeling of cluster 1 diffuse large B-cell lymphoma reveals transformation from marginal zone lymphoma
Blood·2025
SF3B1 mutation accelerates the development of CLL via activation of the mTOR pathway
JCI Insight·2025· 1 citedOpen Access
Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-X <sub>L</sub> degradation to overcome cancer chemoresistance
2025· 7 citedOpen Access
The Evolution and Subtypes of Waldenstrom Macroglobulinemia: Findings from a Multi-omic Analysis of 249 Treatment Naive MYD88L265P Mutated Patients.
2025· 2 citedOpen Access
Abstract 5177: Modeling 6q deletion and MYD88L265P-driven B-cell lymphomas in mice reveals early lymphomagenesis mechanisms and identifies the putative cell of origin
Cancer Research·2025
Development and characterization of the novel <i>MYD88</i> mutated, 6q deleted <scp>BCWM</scp>.2 cell line for Waldenström macroglobulinaemia
British Journal of Haematology·2025· 1 citedOpen Access
Characterization and Experimental Use of Multiple Myeloma Bone Marrow Endothelial Cells and Progenitors
International Journal of Molecular Sciences·2024Open Access
A Novel Ribonuclease Targeting Small Molecule RNA-Degrader (MYC-RiboTAC) Overcomes MYC Dependency in Multiple Myeloma
Blood·2024Open Access
Bone Marrow Spatial Signatures Predict Survival Outcomes and Toxicities after CAR-T Therapy in Patients with Relapsed/Refractory Multiple Myeloma
Blood·2024
Establishment of a Novel Waldenström's Macroglobulinemia (WM) Cell Line Bcwm.2 with Del6q and Unique MYD88S243N, LYNI297N, SPI1Q227E Mutations and That Shows Robust <i>In Vivo</i> Engraftment in SCID NOD Mice
Blood·2024
<i>Discovery of Undocumented, Cancer-Specific and Pro-Inflammatory Isoforms of WNK2 That Are Highly Expressed in MYD88 Mutated Waldenström's Macroglobulinemia and Represent Novel Therapeutic Targets.</i>
Blood·2024Open Access
Characterization and Experimental Use of Multiple Myeloma Bone Marrow Endothelial Cells and Progenitors
Preprints.org·2024Open Access
Primary cutaneous <scp>EBV</scp>+ extranodal <scp>NK</scp>/T‐cell lymphoma of gamma/delta T‐cell lineage in the posttransplantation setting
Journal of Cutaneous Pathology·2024· 1 citedOpen Access
Author Correction: The Cyclophilin A–CD147 complex promotes the proliferation and homing of multiple myeloma cells
Nature Medicine·2024Open Access
Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma
Blood·2024· 17 citedOpen Access
Abstract 5186: Spatial single-cell deconvolution of the bone marrow microenvironment to define predictive biomarker for response to immunotherapy in patients treated with a check point inhibitor in smoldering multiple myeloma, phase II trial of nivolumab in combination with lenalidomide and low dose dexamethasone
Cancer Research·2024
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Frequent Co-authors

Kenneth C. Anderson(25), Teru Hideshima(19), Nikhil C. Munshi(19), Paul G. Richardson(15), Yu‐Tzu Tai(15), Tomasz Sewastianik(11), Dharminder Chauhan(9), Noopur Raje(6), Giada Bianchi(6), Steven P. Treon(6), Catherine J. Wu(6), Klaus Podar(5), Constantine S. Mitsiades(5), Donna Neuberg(5), Elisa ten Hacken(5), Aldo M. Roccaro(5), Irene M. Ghobrial(5), Mehmet Samur(5), Mariateresa Fulciniti(5), Anthony Letai(4)