Derk J. Hogenkamp

University of California, Irvine — United States

Neuroscience · Life Sciences

18h-index1.1kcitations60works2.82yr avg
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Research Topics

Neuroscience and Neuropharmacology Research(28), Nicotinic Acetylcholine Receptors Study(16), Receptor Mechanisms and Signaling(9), Ion channel regulation and function(8), Pharmacological Receptor Mechanisms and Effects(8)

Publications60 total

A conifer metabolite corrects episodic ataxia type 1 by voltage sensor–mediated ligand activation of Kv1.1
Proceedings of the National Academy of Sciences·2024· 3 citedOpen Access
Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines
Communications Biology·2024· 5 citedOpen Access
Enhancing cognitive recovery in chronic traumatic brain injury through simultaneous allosteric modulation of α7 nicotinic acetylcholine and α5 GABAA receptors
Experimental Neurology·2024· 2 citedOpen Access
Ophthalmate is a new regulator of motor functions via CaSR: implications for movement disorders
Brain·2024· 4 citedOpen Access
The molecular basis for KCNQ3 isoform-selective activity of carnosic acid
Biophysical Journal·2024Open Access
Enhancing cognitive function in chronic TBI: The Role of α7 nicotinic acetylcholine receptor modulation
Experimental Neurology·2023· 4 citedOpen Access
Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener
Communications Biology·2023· 16 citedOpen Access
Allosteric modulators of the δ GABAA receptor subtype demonstrate a therapeutic effect in morphine-antinociceptive tolerance and withdrawal in mice
Neuropharmacology·2022· 3 citedOpen Access
<scp>KCNQ5</scp> activation by tannins mediates vasorelaxant effects of barks used in Native American botanical medicine
The FASEB Journal·2022· 10 citedOpen Access
Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor
Neurobiology of Stress·2019· 63 citedOpen Access
Positive allosteric modulation of the α7 nicotinic acetylcholine receptor as a treatment for cognitive deficits after traumatic brain injury
PLoS ONE·2019· 26 citedOpen Access
Enaminone Modulators of Extrasynaptic α4β3δ γ-Aminobutyric AcidA Receptors Reverse Electrographic Status Epilepticus in the Rat After Acute Organophosphorus Poisoning
Frontiers in Pharmacology·2019· 14 citedOpen Access
Positive allosteric modulators of nonbenzodiazepine γ-aminobutyric acidA receptor subtypes for the treatment of chronic pain
Pain·2018· 11 cited
Role of β 2/3 -specific GABA-A receptor isoforms in the development of hippocampus kindling epileptogenesis
Epilepsy & Behavior·2018· 10 cited
Allosteric modulation of nicotinic and GABA A receptor subtypes differentially modify autism-like behaviors in the BTBR mouse model
Neuropharmacology·2017· 32 cited
First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288
Journal of Psychopharmacology·2017· 55 citedOpen Access
Positive allosteric modulation of the α7 nicotinic acetylcholine receptor reverses chronic cognitive deficits after TBI
Biochemical Pharmacology·2015
Pharmacological profile of a 17β-heteroaryl-substituted neuroactive steroid
Psychopharmacology·2014· 17 cited
The positive allosteric modulator of nicotinic alpha 7 cholinergic receptor, AVL-3288, stimulates cathecolamine release in the prefrontal cortex and nucleus accumbens shell of adolescent rats: potential utility in ADHD?
UNICA IRIS Institutional Research Information System (University of Cagliari)·2014
Limited central side effects of a β-subunit subtype-selective GABA<sub>A</sub> receptor allosteric modulator
Journal of Psychopharmacology·2013· 11 cited
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Frequent Co-authors

Kelvin W. Gee(27), Timothy Johnstone(21), Ryan F. Yoshimura(15), Edward R. Whittemore(12), Minhtam Tran(12), Richard M. Woodward(7), Jon E. Hawkinson(6), Nancy C. Lan(6), Richard B. Carter(6), Geoffrey W. Abbott(6), James D. Belluzzi(5), Rían W. Manville(5), Manuel Acosta-Burruel(4), Wen-Yen Li(4), Catherine L. Kimbrough(3), Jincheng Huang(3), John Drewe(3), Victor I. Ilyin(3), Phong Nguyen(3), David J. Titus(3)