Gengfu Xiao

Chinese Academy of Sciences — China

Medicine · Health Sciences

43h-index22.0kcitations151works5.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(41), Viral Infections and Outbreaks Research(28), Mosquito-borne diseases and control(26), Viral Infections and Vectors(26), Prion Diseases and Protein Misfolding(19)

Publications150 total

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors
Advanced Science·2025Open Access
An orally available 4 <i>'</i> -fluorouridine prodrug inhibits SFTSV and LCMV infection
Journal of Virology·2025Open Access
Discovery and mechanistic insights of dibenzoylmethane as a broad spectrum inhibitor of coronavirus
PLoS Pathogens·2025Open Access
Eltrombopag, an FDA-approved drug, inhibits dengue virus type 2 by targeting NS2B-NS3 protease
Virologica Sinica·2025· 5 citedOpen Access
Substrate recognition and cleavage mechanism of the monkeypox virus core protease
Nature·2025· 5 cited
Structure-guided design of a prefusion GPC trimer induces neutralizing responses against LASV
npj Vaccines·2025· 4 citedOpen Access
Functional Characterization of a Lassa Virus Fusion Inhibitor Adaptive Mutant
Zoonoses·2025· 2 citedOpen Access
Integrative analysis of the metabolomes and transcriptomes of Ebola virus-infected cells: Uncovering pathways related to hepatic apoptosis
Genes & Diseases·2024Open Access
A full-length glycoprotein mRNA vaccine confers complete protection against severe fever with thrombocytopenia syndrome virus, with broad-spectrum protective effects against bandaviruses
Journal of Virology·2024· 17 citedOpen Access
Functional Characterization of a Lassa Virus Fusion Inhibitor Adaptive Mutant
Research Square (Research Square)·2024Open Access
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
Signal Transduction and Targeted Therapy·2024· 19 citedOpen Access
A nanoluciferase SFTSV for rapid screening antivirals and real-time visualization of virus infection in mice
EBioMedicine·2024· 8 citedOpen Access
Regulation of the WNT-CTNNB1 signaling pathway by severe fever with thrombocytopenia syndrome virus in a cap-snatching manner
mBio·2023· 4 citedOpen Access
Protection of the receptor binding domain (RBD) dimer against SARS-CoV-2 and its variants
Journal of Virology·2023· 4 citedOpen Access
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir
Nature Communications·2023· 95 citedOpen Access
Ebola virus VP35 perturbs type I interferon signaling to facilitate viral replication
Virologica Sinica·2023· 16 citedOpen Access
A viral RNA-dependent RNA polymerase inhibitor VV116 broadly inhibits human coronaviruses and has synergistic potency with 3CLpro inhibitor nirmatrelvir
Signal Transduction and Targeted Therapy·2023· 21 citedOpen Access
Identification of tanshinone I as cap-dependent endonuclease inhibitor with broad-spectrum antiviral effect
Journal of Virology·2023· 13 citedOpen Access
CCR2 is a host entry receptor for severe fever with thrombocytopenia syndrome virus
Science Advances·2023· 43 citedOpen Access
Impact of SARS-CoV-2 envelope protein mutations on the pathogenicity of Omicron XBB
Cell Discovery·2023· 16 citedOpen Access
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Frequent Co-authors

Leike Zhang(29), Weijuan Shang(11), Hualiang Jiang(9), Xing‐Lou Yang(7), Zheng‐Li Shi(7), Zihe Rao(7), Yan Wu(7), Xiaming Jiang(7), Wei Liu(7), Ke Peng(7), Zhenming Jin(6), Yechun Xu(6), Haitao Yang(6), Fēi Dèng(6), Yuan Sun(6), Hao Li(6), Xiaoyan Pan(6), Xiaoyu Du(5), Yao Zhao(5), Yinkai Duan(5)