Thomas Helleday

Karolinska University Hospital — Sweden

Biochemistry, Genetics and Molecular Biology · Life Sciences

83h-index35.4kcitations685works2.22yr avg
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Research Topics

DNA Repair Mechanisms(249), PARP inhibition in cancer therapy(111), CRISPR and Genetic Engineering(68), Epigenetics and DNA Methylation(47), Cancer-related Molecular Pathways(44)

Publications685 total

Mitochondria-Directed OGG1 Organocatalytic Switches Restore Organelle Function Under Oxidative Stress
2025
Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1
RSC Chemical Biology·2025Open Access
Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches for DNA Repair Enzyme OGG1
Journal of Medicinal Chemistry·2025· 1 citedOpen Access
Author response for "Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1"
2025
RareFoldGPCR: Agonist Design Beyond Natural Amino Acids
2025· 1 citedOpen Access
TGF-α/EGFR chemotaxis drives lymphatic metastasis and early immune suppression, revealing a repositionable therapeutic target in breast cancer
2025Open Access
In vivo antiviral activity of two newly developed compounds reduces the harmful effects of ZIKV in chicken embryos
Biochemical and Biophysical Research Communications·2025
The anabolic steroid stanozolol is a potent inhibitor of human <scp>MutT</scp> homolog 1
FEBS Letters·2025Open Access
Mitotic MTH1 inhibitor karonudib kills epithelial ovarian cancer independent of platinum sensitivity
Experimental Hematology and Oncology·2025Open Access
Blind De Novo Design of Dual Cyclic Peptide Agonists Targeting GCGR and GLP1R
2025· 2 citedOpen Access
Giving an Enzyme Scissors: Serotonin Derivatives as Potent Organocatalytic Switches of DNA Repair Enzyme OGG1
2025· 1 citedOpen Access
Uracil-induced replication stress drives mutations, genome instability, anti-cancer treatment efficacy, and resistance
Molecular Cell·2025· 7 citedOpen Access
Organocatalytic Switches of DNA Glycosylase OGG1 Catalyze a Highly Efficient AP‐Lyase Function
Chemistry - A European Journal·2025· 8 citedOpen Access
Author response for "Nucleobase catalysts for the enzymatic activation of 8-oxoguanine DNA glycosylase 1"
2025
Organocatalytic switches of OGG1 control ultrafast abasic site incision through compound pKa
2025Open Access
Virtual fragment screening for DNA repair inhibitors in vast chemical space
Nature Communications·2025· 9 citedOpen Access
Supplementary Movie S2 from MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
2025Open Access
Supplementary Data S1 from MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
2025Open Access
Data from MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
2025Open Access
Supplementary Movie S1 from MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
2025Open Access
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Frequent Co-authors

Niklas Schultz(12), Ann‐Sofie Jemth(8), Cecilia Lundin(7), Olga Loseva(7), Kumar Sanjiv(7), Helen E. Bryant(6), Eva Petermann(6), Ulrika Warpman Berglund(6), Fredrik Johansson(5), Natalia Issaeva(4), Jiří Bártek(4), Claus Storgaard Sørensen(4), Tobias Koolmeister(4), Camilla Göktürk(4), Therese Pham(4), Elisée Wiita(4), Martin Scobie(4), Petra Groth(3), Randi G. Syljuåsen(3), Paweł Baranczewski(3)