Hans Koll

Roche (Switzerland) — Switzerland

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index2.0kcitations29works8.02yr avg
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Research Topics

Protein purification and stability(11), Monoclonal and Polyclonal Antibodies Research(10), Mitochondrial Function and Pathology(6), Viral Infectious Diseases and Gene Expression in Insects(5), Protein Structure and Dynamics(3)

Publications29 total

Optimizing Early Clinical Investigations in Cancer Immunotherapy: The Translational Journey of RG6292, a Novel, Selective Treg‐Depleting Antibody
Clinical Pharmacology & Therapeutics·2024· 8 cited
Enhancing Selectivity of Protein Biopharmaceuticals in Ion Exchange Chromatography through Addition of Organic Modifiers
International Journal of Molecular Sciences·2023· 4 citedOpen Access
CD25-Treg-depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity
Nature Cancer·2020· 187 citedOpen Access
Abstract 4553: The CD25 antibody RG6292 selectively depletes Tregs while preserving IL-2 signaling and CTL activity for tumor control
Cancer Research·2020· 4 cited
CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD
2020
Detection of a phosphorylated glycine-serine linker in an IgG-based fusion protein
mAbs·2016· 16 citedOpen Access
Developability Assessment During the Selection of Novel Therapeutic Antibodies
Journal of Pharmaceutical Sciences·2015· 234 cited
A novel approach to investigate the effect of methionine oxidation on pharmacokinetic properties of therapeutic antibodies
mAbs·2014· 107 citedOpen Access
Low Level Sequence Variant Analysis of Recombinant Proteins: An Optimized Approach
PLoS ONE·2012· 39 citedOpen Access
Determination of Antibody Glycosylation by Mass Spectrometry
Methods in molecular biology·2012· 6 cited
Strategies for the Assessment of Protein Aggregates in Pharmaceutical Biotech Product Development
Pharmaceutical Research·2010· 345 citedOpen Access
Short‐hairpin‐RNA‐mediated silencing of fucosyltransferase 8 in Chinese‐hamster ovary cells for the production of antibodies with enhanced antibody immune effector function
Biotechnology and Applied Biochemistry·2008· 30 cited
Crystal Structures of Active Src Kinase Domain Complexes
Journal of Molecular Biology·2005· 76 cited
Crystal structure of Src kinase domain in complex with CGP77675
2005
Crystal structure of Src kinase domain
2005
Crystal structure of Src kinase domain in complex with Purvalanol A
2005
Zur Handhabung und Übertragung Tiefgefrorener Rinderembryonen
veterinär spiegel·2003
Biodegradable recombinant human erythropoietin loaded microspheres prepared from linear and star-branched block copolymers: Influence of encapsulation technique and polymer composition on particle characteristics
Journal of Controlled Release·1999· 75 cited
Erythropoietin loaded microspheres prepared from biodegradable LPLG–PEO–LPLG triblock copolymers: protein stabilization and in-vitro release properties
Journal of Controlled Release·1998· 113 cited
Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics
European Journal of Pharmaceutics and Biopharmaceutics·1998· 114 cited
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Frequent Co-authors

Gerhard Winter(4), Thomas Kissel(4), Rosemary A. Stuart(4), Walter Neupert(4), C.B. Breitenlechner(4), Norman Kairies(4), Konrad Honold(4), Stefan Scheiblich(4), S. Koch(4), Richard A. Engh(4), Bernard Guiard(3), Jörg T. Regula(3), Apollon Papadimitriou(3), Maria Amann(3), Estelle Marrer‐Berger(3), Christophe Boetsch(3), Sara Belli(3), Michael M. Morlock(3), E. Greiter(3), Wolfgang Schaefer(3)