Nigel J. O’Neil

University of British Columbia — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index3.8kcitations67works1.82yr avg
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Research Topics

DNA Repair Mechanisms(34), Genetics, Aging, and Longevity in Model Organisms(25), PARP inhibition in cancer therapy(20), CRISPR and Genetic Engineering(16), Genomics and Chromatin Dynamics(6)

Publications67 total

59 THE BC RESEARCH CONSORTIUM OF NEURO-ONCOLOGY (RECON)
Neuro-Oncology Advances·2025Open Access
Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies
DNA repair·2025Open Access
Deep structure–function analysis of the endonuclease Mus81 with dominant mutational scanning
Proceedings of the National Academy of Sciences·2025· 1 citedOpen Access
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
Science·2025· 12 cited
The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in <i>Caenorhabditis elegans</i>
G3 Genes Genomes Genetics·2025Open Access
Abstract 1467: Revealing therapeutically relevant states of cohesin through dominant-negative mutational mapping of Smc1 as a synthetic lethal anti-cancer approach
Cancer Research·2025
The transsulfuration pathway suppresses the embryonic lethal phenotype of glutathione reductase mutants in Caenorhabditis elegans
2025Open Access
Distribution of haploid chromosomes into separate nuclei in two pathogenic fungi
2024· 3 citedOpen Access
Mapping of DDX11 genetic interactions defines sister chromatid cohesion as the major dependency
G3 Genes Genomes Genetics·2024Open Access
Supplementary Figure 1 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 4 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 5 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 2 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 6 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 1 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure Legend from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 6 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 3 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Supplementary Figure 5 from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
Data from Glioblastoma Cells Containing Mutations in the Cohesin Component &lt;i&gt;STAG2&lt;/i&gt; Are Sensitive to PARP Inhibition
2023Open Access
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Frequent Co-authors

Philip Hieter(20), Ann M. Rose(13), Melanie L. Bailey(12), Derek M. van Pel(10), David A. Solomon(7), Todd Waldman(7), David L. Baillie(7), Patricia E. Kuwabara(5), Jillian L. Youds(5), Phil Hieter(4), Jordan D. Ward(4), Simon J. Boulton(4), L. M. Kuervers(4), Greg Vatcher(4), Akil Hamza(4), Frank B. Ye(3), Peter C. Stirling(3), Julie S. Martin(3), Erin J. Gilchrist(3), Marco A. Marra(3)