Daniel N. Bolon

University of Massachusetts Chan Medical School — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

43h-index6.0kcitations138works4.92yr avg
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Research Topics

Heat shock proteins research(34), Protein Structure and Dynamics(31), Evolution and Genetic Dynamics(29), Computational Drug Discovery Methods(18), RNA and protein synthesis mechanisms(17)

Publications138 total

Cooperativity and communication between the active sites of the dimeric SARS-CoV-2 main protease
Science Advances·2026Open Access
Mutational scan of self-cleavage by HIV-1 protease provides new views of a conformationally dynamic mechanism
2025Open Access
Cooperativity and Communication between the Active Sites of the Dimeric SARS-CoV-2 Main Protease
2025Open Access
Molecular mechanisms of drug resistance and compensation in SARS-CoV-2 main protease: the interplay between E166 and L50
mBio·2025· 8 citedOpen Access
Molecular Mechanisms of Drug Resistance and Compensation in SARS-CoV-2 Main Protease: The Interplay Between E166 and L50
2025· 1 citedOpen Access
Dominant negative mutations in yeast Hsp90 indicate triage decision mechanism targeting client proteins for degradation
Molecular Biology of the Cell·2024· 2 citedOpen Access
Contributions of Hyperactive Mutations in M<sup>pro</sup> from SARS-CoV-2 to Drug Resistance
ACS Infectious Diseases·2024· 19 citedOpen Access
Dominant negative mutations in yeast Hsp90 reveal triage decision mechanism targeting client proteins for degradation
2024· 8 citedOpen Access
Contributions of hyperactive mutations in M <sup>pro</sup> from SARS-CoV-2 to drug resistance
2023Open Access
Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection
Cell Reports·2023· 14 citedOpen Access
Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV-2 Main Protease
ACS Infectious Diseases·2023· 37 citedOpen Access
Systematic analyses of the resistance potential of drugs targeting SARS-CoV-2 main protease
2023· 5 citedOpen Access
A complete allosteric map of a GTPase switch in its native cellular network
Cell Systems·2023· 19 citedOpen Access
Mutational fitness landscape and drug resistance
Current Opinion in Structural Biology·2023· 5 citedOpen Access
Defining the substrate envelope of SARS-CoV-2 main protease to predict and avoid drug resistance
Nature Communications·2022· 122 citedOpen Access
Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
eLife·2022· 123 citedOpen Access
Sequence dependencies and biophysical features both govern cleavage of diverse cut‐sites by <scp>HIV</scp> protease
Protein Science·2022· 3 citedOpen Access
Author response: Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms
2022· 2 citedOpen Access
Sequence dependencies and biophysical features both govern cleavage of diverse cut-sites by HIV protease
2022Open Access
A complete allosteric map of a GTPase switch in its native network
2022· 5 citedOpen Access
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Frequent Co-authors

Jeffrey D. Jensen(11), Celia A. Schiffer(10), Julia M. Flynn(9), Konstantin B. Zeldovich(8), Claudia Bank(8), Robert T. Sauer(7), Tania A. Baker(7), Ryan T. Hietpas(6), Benjamin P. Roscoe(6), Nicholas Renzette(6), Ping Liu(6), Jennifer Wang(6), Timothy F. Kowalik(6), Robert W. Finberg(6), Parul Mishra(6), Neşe Kurt Yılmaz(5), Stephen L. Mayo(4), Li Jiang(4), Robert A. Grant(3), Greg L. Hersch(3)