Sandra L. Siedlak

Case Western Reserve University — United States

Medicine · Health Sciences

61h-index13.1kcitations178works2.52yr avg
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Research Topics

Alzheimer's disease research and treatments(101), Mitochondrial Function and Pathology(25), Cholinesterase and Neurodegenerative Diseases(23), Parkinson's Disease Mechanisms and Treatments(22), Prion Diseases and Protein Misfolding(16)

Publications177 total

Space-Like Irradiation Exacerbated Cognitive Deficits and Amyloid Pathology in CRND8 Mouse Model of Alzheimer’s Disease
Journal of Alzheimer s Disease·2024· 2 citedOpen Access
Ferritin is closely associated with microglia in amyotrophic lateral sclerosis
Journal of Neuropathology & Experimental Neurology·2024· 3 citedOpen Access
Damaged mitochondria coincide with presynaptic vesicle loss and abnormalities in alzheimer’s disease brain
Acta Neuropathologica Communications·2023· 40 citedOpen Access
Selective Detection of Misfolded Tau From Postmortem Alzheimer’s Disease Brains
Frontiers in Aging Neuroscience·2022· 25 citedOpen Access
C19orf12 ablation causes ferroptosis in mitochondrial membrane protein-associated with neurodegeneration
Free Radical Biology and Medicine·2022· 26 citedOpen Access
METTL3-dependent RNA m6A dysregulation contributes to neurodegeneration in Alzheimer’s disease through aberrant cell cycle events
Molecular Neurodegeneration·2021· 180 citedOpen Access
Oxidative Stress Signaling in Blast TBI-Induced Tau Phosphorylation
Antioxidants·2021· 13 citedOpen Access
<i>VPS35</i> D620N knockin mice recapitulate cardinal features of Parkinson’s disease
Aging Cell·2021· 47 citedOpen Access
Skin α-Synuclein Aggregation Seeding Activity as a Novel Biomarker for Parkinson Disease
JAMA Neurology·2020· 239 citedOpen Access
Vitamin C is a source of oxoaldehyde and glycative stress in age‐related cataract and neurodegenerative diseases
Aging Cell·2020· 23 citedOpen Access
Mfn2 Ablation in the Adult Mouse Hippocampus and Cortex Causes Neuronal Death
Cells·2020· 61 citedOpen Access
Human Tau Isoform Aggregation and Selective Detection of Misfolded Tau from Post-Mortem Alzheimer’s Disease Brains
2020· 6 citedOpen Access
The sterol regulatory element‐binding protein 2 is dysregulated by tau alterations in Alzheimer disease
Brain Pathology·2018· 19 citedOpen Access
Conditional Haploinsufficiency of β-Catenin Aggravates Neuronal Damage in a Paraquat-Based Mouse Model of Parkinson Disease
Molecular Neurobiology·2018· 9 citedOpen Access
Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles
Cell Metabolism·2018· 49 citedOpen Access
Rab10 Phosphorylation is a Prominent Pathological Feature in Alzheimer’s Disease
Journal of Alzheimer s Disease·2018· 48 citedOpen Access
Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex
Molecular Neurodegeneration·2018· 103 citedOpen Access
Inhibition of mitochondrial fragmentation protects against Alzheimer’s disease in rodent model
Human Molecular Genetics·2017· 173 citedOpen Access
TMEM230 Accumulation in Granulovacuolar Degeneration Bodies and Dystrophic Neurites of Alzheimer’s Disease
Journal of Alzheimer s Disease·2017· 11 cited
Ablation of Mitochondria Fusion Protein Mfn2 causes an Oxidative Stress Response and Eventual Neuronal Death in the Hippocampus and Cortex
The FASEB Journal·2017
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Frequent Co-authors

George Perry(42), Mark A. Smith(32), Xiongwei Zhu(23), Akihiko Nunomura(15), Gjumrakch Aliev(10), Peggy L.R. Harris(10), Xinglong Wang(10), Paula I. Moreira(9), Hyoung‐gon Lee(9), Hisashi Fujioka(8), Rudy J. Castellani(8), Massimo Tabaton(7), Wenzhang Wang(6), Harry V. Vinters(5), Shun Shimohama(5), Robert B. Petersen(5), Gemma Casadesús(5), Craig Atwood(4), Ayla Cash(4), Arun K. Raina(4)