Irving L.M.H. Aye

University of Cambridge — United Kingdom

Medicine · Health Sciences

22h-index2.6kcitations50works3.42yr avg
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Research Topics

Pregnancy and preeclampsia studies(30), Birth, Development, and Health(16), Gestational Diabetes Research and Management(14), Reproductive System and Pregnancy(9), Epigenetics and DNA Methylation(6)

Publications50 total

Interactions between placental Hofbauer cells and <i>L. monocytogenes</i> change throughout gestation
Science Immunology·2025· 4 citedOpen Access
The human placenta and its role in reproductive outcomes revisited
Physiological Reviews·2025· 10 citedOpen Access
Emerging models of human and non-human primate placental development – Centre for Trophoblast Research 17th annual meeting 2024
Biology Open·2024· 2 citedOpen Access
Human placental cells are resistant to SARS-CoV-2 infection and replication
Wellcome Open Research·2024· 1 citedOpen Access
Human placental cells are resistant to SARS-CoV-2 infection and replication
Wellcome Open Research·2024Open Access
Novel 3D in vitro human placenta-on-a-chip model derived using human trophoblast stem cells differentiated towards syncytiotrophoblasts and extravillous trophoblasts to mimic both villi and implantation sides of the placenta.
Placenta·2023
The human placenta exhibits a unique transcriptomic void
Cell Reports·2023· 11 citedOpen Access
Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice
2023· 2 citedOpen Access
Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice
2023· 1 citedOpen Access
Physiologically relevant culture medium Plasmax improves human placental trophoblast stem cell function
American Journal of Physiology-Cell Physiology·2023· 5 citedOpen Access
The human placenta exhibits a unique transcriptomic void
2022· 3 citedOpen Access
Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress
Frontiers in Cell and Developmental Biology·2022· 23 citedOpen Access
Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-coA metabolism and histone acetylation
Communications Biology·2022· 14 citedOpen Access
Insulin Increases Adipose Adiponectin in Pregnancy by Inhibiting Ubiquitination and Degradation: Impact of Obesity
The Journal of Clinical Endocrinology & Metabolism·2021· 18 citedOpen Access
Placental polyamines regulate acetyl-coA and histone acetylation in a sex-specific manner
2021· 3 citedOpen Access
Insulin-stimulated adiponectin secretion in pregnancy is mediated by inhibition of adiponectin ubiquitination and degradation and is impaired in obesity
2021Open Access
Placental energy metabolism in health and disease—significance of development and implications for preeclampsia
American Journal of Obstetrics and Gynecology·2020· 144 citedOpen Access
Placental polyamine metabolism differs by fetal sex, fetal growth restriction, and preeclampsia
JCI Insight·2018· 79 citedOpen Access
Maternal group 2 innate lymphoid cells contribute to fetal growth and protection from endotoxin-induced abortion in mice
2018· 9 citedOpen Access
Retosiban Prevents Stretch-Induced Human Myometrial Contractility and Delays Labor in Cynomolgus Monkeys
The Journal of Clinical Endocrinology & Metabolism·2017· 13 citedOpen Access
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Frequent Co-authors

Theresa L. Powell(18), Thomas Jansson(15), Francesca Gaccioli(13), D. Stephen Charnock‐Jones(11), Gordon C. S. Smith(10), Jeffrey A. Keelan(10), Susanne Lager(6), Fredrick J. Rosario(6), Sungsam Gong(5), Giulia Avellino(5), Vanessa Ramírez(4), Peter J. Mark(4), Benjamin Jenkins(4), Catherine Aiken(3), Ambika T. Singh(3), Emma Cook(3), Albert Koulman(3), B. J. Waddell(3), Elisa Balmas(3), Batika M.J. Rana(3)