Laura McDonald

Hospital for Sick Children — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

17h-index1.3kcitations26works4.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Bone Metabolism and Diseases(4), Cellular Mechanics and Interactions(3), Cancer Treatment and Pharmacology(3), Protein Structure and Dynamics(2), Bacterial Genetics and Biotechnology(2)

Publications26 total

Genetic suppression features ABHD18 as a Barth syndrome therapeutic target
Nature·2025· 4 cited
Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging
Cell Reports·2021· 21 citedOpen Access
Salt-inducible kinase (SIK) inhibition is protective in a mouse model of asthma
2021· 1 citedOpen Access
MNK Inhibition Sensitizes <i>KRAS</i> -Mutant Colorectal Cancer to mTORC1 Inhibition by Reducing eIF4E Phosphorylation and c-MYC Expression
Cancer Discovery·2020· 91 citedOpen Access
RUNX1 Is a Driver of Renal Cell Carcinoma Correlating with Clinical Outcome
Cancer Research·2020· 49 citedOpen Access
BRCA1 Attenuates Progesterone Effects on Proliferation and NFκB Activation in Normal Human Mammary Epithelial Cells
Journal of Mammary Gland Biology and Neoplasia·2019· 14 citedOpen Access
Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents
Bioorganic & Medicinal Chemistry Letters·2019· 44 citedOpen Access
A Novel Small-Molecule Inhibitor of MRCK Prevents Radiation-Driven Invasion in Glioblastoma
Cancer Research·2018· 37 citedOpen Access
Google searches do not correlate with melanoma incidence in majority English speaking countries
npj Digital Medicine·2018· 7 citedOpen Access
Abstract 1933: A novel small molecule inhibitor of MRCK shows utility in blocking radiation induced invasion of glioblastoma cells <i>in vitro</i> and <i>in vivo</i>
Cancer Research·2018
Discovery of Potent and Selective MRCK Inhibitors with Therapeutic Effect on Skin Cancer
Cancer Research·2018· 48 citedOpen Access
Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling
Nature·2017· 223 citedOpen Access
Abstract LB-228: Identifying small molecule inhibitors of Fascin 1 using fragment-based drug discovery
Cancer Research·2017
Secreted CLIC3 drives cancer progression through its glutathione-dependent oxidoreductase activity
Nature Communications·2017· 113 citedOpen Access
Abstract A113: A fragment-based approach towards the identification of small molecule inhibitors of fascin 1
Molecular Cancer Therapeutics·2015
Runx2 contributes to the regenerative potential of the mammary epithelium
Scientific Reports·2015· 34 citedOpen Access
Salmonella Disrupts Host Endocytic Trafficking by SopD2-Mediated Inhibition of Rab7
Cell Reports·2015· 104 citedOpen Access
Annexin A8 Identifies a Subpopulation of Transiently Quiescent c-Kit Positive Luminal Progenitor Cells of the Ductal Mammary Epithelium
PLoS ONE·2015· 15 citedOpen Access
Structure of CbpA J-Domain Bound to the Regulatory Protein CbpM Explains Its Specificity and Suggests Evolutionary Link between CbpM and Transcriptional Regulators
PLoS ONE·2014· 9 citedOpen Access
Coiled-Coil Helix Rotation Selects Repressing or Activating State of Transcriptional Regulator DhaR
Structure·2014· 23 citedOpen Access
page 1 of 2Next →

Frequent Co-authors

Karen Blyth(9), Heather J. McKinnon(8), Justin Bower(7), Daniel R. Croft(6), Martin J. Drysdale(6), Christopher H. Gray(6), Mokdad Mezna(6), Laura M. Machesky(5), Ewan R. Cameron(5), Jennifer Konczal(5), Rong Shi(4), Mirosław Cygler(4), Owen J. Sansom(4), Nicola Ferrari(4), Patricia McConnell(4), Mairi Sime(4), Michael F. Olson(4), A.W. Schuettelkopf(4), James C. Neil(3), Joanne Edwards(3)