Darren Fegley

United States Food and Drug Administration — United States

Medicine · Health Sciences

11h-index3.3kcitations11works0.02yr avg
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Research Topics

Cannabis and Cannabinoid Research(8), Forensic Toxicology and Drug Analysis(4), Neurotransmitter Receptor Influence on Behavior(3), Sleep and Wakefulness Research(3), Neuroscience and Neuropharmacology Research(2)

Publications11 total

Scientific and Regulatory Policy Committee Best Practices: Documentation of Sexual Maturity by Microscopic Evaluation in Nonclinical Safety Studies
Toxicologic Pathology·2021· 15 cited
Challenges and strategies to facilitate formulation development of pediatric drug products: Safety qualification of excipients
International Journal of Pharmaceutics·2017· 39 cited
Increased fear‐ and stress‐related anxiety‐like behavior in mice lacking tuberoinfundibular peptide of 39 residues
Genes Brain & Behavior·2008· 46 citedOpen Access
Erratum: Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
Nature Neuroscience·2006· 23 cited
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia
Neuropharmacology·2005· 80 cited
Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus
Nature Neuroscience·2005· 236 cited
Stimulation of Endocannabinoid Formation in Brain Slice Cultures through Activation of Group I Metabotropic Glutamate Receptors
Molecular Pharmacology·2005· 192 cited
An endocannabinoid mechanism for stress-induced analgesia
Nature·2005· 761 cited
Characterization of the Fatty Acid Amide Hydrolase Inhibitor Cyclohexyl Carbamic Acid 3′-Carbamoyl-biphenyl-3-yl Ester (URB597): Effects on Anandamide and Oleoylethanolamide Deactivation
Journal of Pharmacology and Experimental Therapeutics·2005· 428 cited
Anandamide transport is independent of fatty-acid amide hydrolase activity and is blocked by the hydrolysis-resistant inhibitor AM1172
Proceedings of the National Academy of Sciences·2004· 232 citedOpen Access
Modulation of anxiety through blockade of anandamide hydrolysis
Nature Medicine·2002· 1.3k cited

Frequent Co-authors

Daniele Piomelli(8), Andrea Duranti(5), Andrea Tontini(5), Marco Mor(5), Giorgio Tarzia(5), Satish Kathuria(3), Silvana Gaetani(2), Andrea G. Hohmann(2), Richard L. Suplita(2), Regina A. Mangieri(2), Judit K. Makara(2), Szilárd Szabó(2), Giuseppe Astarita(2), Silvia Rivara(2), Tamás F. Freund(2), Fernando Valiño(1), Giovanna La Rana(1), Antonio Calignano(1), Arcangela Giustino(1), Maria Tattoli(1)