Paul M. O’Neill

University of Liverpool — United Kingdom

Medicine · Health Sciences

61h-index14.5kcitations299works4.82yr avg
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Research Topics

Malaria Research and Control(125), Computational Drug Discovery Methods(54), Synthesis and Catalytic Reactions(42), HIV/AIDS drug development and treatment(31), Mosquito-borne diseases and control(26)

Publications298 total

Potent Preorganized Pyrazolidine Cyclophilin D Inhibitors Prevent Mitochondrial and Organ Injury in a Mouse Pancreatitis Disease Model
Journal of Medicinal Chemistry·2025Open Access
Novel small molecule cyclophilin D inhibitors with improved drug-like properties for mitochondrial protection in acute pancreatitis
Pancreatology·2025
Inhibition of PRC2 enables self-renewal of blastoid-competent naive pluripotent stem cells from chimpanzee
Cell stem cell·2025· 3 citedOpen Access
Novel antimalarial 3-substituted quinolones isosteres with improved pharmacokinetic properties
European Journal of Medicinal Chemistry·2024· 1 cited
Small molecule therapeutics for neutralising venom toxins – a drug discovery approach
Toxicon·2024· 1 cited
A Phase 1, Randomized, Double‐Blind, Placebo‐Controlled, Single Ascending Dose Trial of AWZ1066S, an Anti‐<i>Wolbachia</i> Candidate Macrofilaricide
Clinical Pharmacology in Drug Development·2024· 3 citedOpen Access
Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement
Scientific Reports·2024· 9 citedOpen Access
Synthesis of Nonsymmetrical 1,2,4,5-Tetraoxanes: Past and Current Routes
WORLD SCIENTIFIC eBooks·2024
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis
Frontiers in Microbiology·2024· 6 citedOpen Access
Optimizing drug discovery for snakebite envenoming via a high-throughput phospholipase A2 screening platform
Frontiers in Pharmacology·2024· 7 citedOpen Access
Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors
Frontiers in Pharmacology·2024· 26 citedOpen Access
Convenient syntheses of 2-acylamino-4-halothiazoles and acylated derivatives using a versatile Boc-intermediate
RSC Advances·2024· 1 citedOpen Access
Design, synthesis and modelling of photoreactive chemical probes for investigating target engagement of plasmepsin IX and X in <i>Plasmodium falciparum</i>
RSC Chemical Biology·2023· 7 citedOpen Access
Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology
2023· 8 citedOpen Access
Dirofilariasis mouse models for heartworm preclinical research
Frontiers in Microbiology·2023· 13 citedOpen Access
Thiazolide Prodrug Esters and Derived Peptides: Synthesis and Activity
ACS Bio & Med Chem Au·2023Open Access
A dirofilariasis mouse model for heartworm preclinical research
2023Open Access
Genome-wide characterization of mitochondrial DNA methylation in human brain
Frontiers in Endocrinology·2023· 23 citedOpen Access
Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-<i>Wolbachia</i> Drug Candidate for a Short-Course Treatment of Filariasis
Organic Process Research & Development·2023· 2 cited
Identification of 2-Aryl-Quinolone Inhibitors of Cytochrome <i>bd</i> and Chemical Validation of Combination Strategies for Respiratory Inhibitors against <i>Mycobacterium tuberculosis</i>
ACS Infectious Diseases·2023· 26 citedOpen Access
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Frequent Co-authors

Stephen A. Ward(35), Patrick G. Bray(18), Giancarlo A. Biagini(18), Paul A. Stocks(9), Nicholas Fisher(8), James L. Maggs(8), Jill Davies(7), Richard K. Amewu(7), Neil G. Berry(7), Victoria Barton(6), Alison E. Shone(6), Shaun R. Hawley(5), Sitthivut Charoensutthivarakul(5), Gemma L. Nixon(5), Peter Gibbons(5), B. Kevin Park(5), Gary H. Posner(4), Amy E. Mercer(4), James Chadwick(4), Stephen Hindley(4)