William A. Schleif

United States Military Academy — United States

Medicine · Health Sciences

50h-index15.1kcitations136works0.02yr avg
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Research Topics

HIV/AIDS drug development and treatment(104), HIV Research and Treatment(102), Click Chemistry and Applications(22), Biochemical and Molecular Research(21), HIV/AIDS Research and Interventions(18)

Publications136 total

Efficacy of Multivalent Adenovirus-Based Vaccine against Simian Immunodeficiency Virus Challenge
Journal of Virology·2009· 35 citedOpen Access
The effect of early versus delayed challenge after vaccination in controlling SHIV 89.6P infection
Virology·2008· 2 citedOpen Access
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase
Bioorganic & Medicinal Chemistry Letters·2008· 24 citedOpen Access
10-Hydroxy-7,8-dihydropyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: Potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants
Bioorganic & Medicinal Chemistry Letters·2008· 20 cited
Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 21 cited
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 37 citedOpen Access
Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors
Bioorganic & Medicinal Chemistry Letters·2007· 28 citedOpen Access
Synthesis of novel HIV protease inhibitors (PI) with activity against PI-resistant virus
Bioorganic & Medicinal Chemistry Letters·2007· 8 citedOpen Access
Early depletion of proliferating B cells of germinal center in rapidly progressive simian immunodeficiency virus infection
Virology·2007· 37 cited
CCDC 619397: Experimental Crystal Structure Determination
The Cambridge Structural Database·2007Open Access
A potent and orally active HIV-1 integrase inhibitor
Bioorganic & Medicinal Chemistry Letters·2006· 36 citedOpen Access
Design of immunogens that present the crown of the HIV-1 V3 loop in a conformation competent to generate 447-52D-like antibodies
Biochemical Journal·2006· 23 citedOpen Access
A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors
Bioorganic & Medicinal Chemistry Letters·2006· 50 citedOpen Access
CCDC 264140: Experimental Crystal Structure Determination
The Cambridge Structural Database·2006Open Access
Cytotoxic T-Lymphocyte Escape Does Not Always Explain the Transient Control of Simian Immunodeficiency Virus SIVmac239 Viremia in Adenovirus-Boosted and DNA-Primed Mamu-A*01-Positive Rhesus Macaques
Journal of Virology·2005· 50 citedOpen Access
Attenuation of Simian Immunodeficiency Virus SIVmac239 Infection by Prophylactic Immunization with DNA and Recombinant Adenoviral Vaccine Vectors Expressing Gag
Journal of Virology·2005· 264 citedOpen Access
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2′ side chains
Bioorganic & Medicinal Chemistry Letters·2005· 22 citedOpen Access
Orally bioavailable highly potent HIV protease inhibitors against PI-resistant virus
Bioorganic & Medicinal Chemistry Letters·2005· 10 citedOpen Access
A human monoclonal antibody neutralizes diverse HIV-1 isolates by binding a critical gp41 epitope
Proceedings of the National Academy of Sciences·2005· 155 citedOpen Access
Vectored Gag and Env but Not Tat Show Efficacy against Simian-Human Immunodeficiency Virus 89.6P Challenge in Mamu-A<sup>*</sup>01-Negative Rhesus Monkeys
Journal of Virology·2005· 77 citedOpen Access
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Frequent Co-authors

Emilio A. Emini(36), Daria J. Hazuda(12), Michael D. Miller(11), Anthony Carella(11), Joseph Kessler(10), Joseph P. Vacca(9), Malcolm MacCoss(8), Sander G. Mills(8), Lorraine Malkowitz(8), Sandra L. Gould(8), Julie A. DeMartino(8), Martin S. Springer(8), Gwen Carver(8), Janet Lineberger(8), Jon H. Condra(7), John W. Shiver(7), Lori J. Gabryelski(7), James P. Guare(7), Karen Holmes(7), Renee Danzeisen(7)