Vikki Spaulding

Memorial — Russia

Immunology and Microbiology · Life Sciences

10h-index852citations18works0.02yr avg
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Research Topics

Immunotherapy and Immune Responses(6), Monoclonal and Polyclonal Antibodies Research(6), T-cell and B-cell Immunology(5), Cancer Immunotherapy and Biomarkers(4), Immune Cell Function and Interaction(4)

Publications18 total

Differential expression of CCR8 in tumors versus normal tissue allows specific depletion of tumor-infiltrating T regulatory cells by GS-1811, a novel Fc-optimized anti-CCR8 antibody
OncoImmunology·2022· 54 citedOpen Access
217 Evaluating biomarkers of JTX-8064 (anti-LILRB2/ILT4 monoclonal antibody) in an ex vivo human tumor histoculture system to inform clinical development
Regular and Young Investigator Award Abstracts·2020· 2 citedOpen Access
Abstract 4532: Preclinical evaluation of JTX-1811, an anti-CCR8 antibody with enhanced ADCC activity, for preferential depletion of tumor-infiltrating regulatory T cells
Cancer Research·2020· 7 cited
Abstract 5007: Preclinical evaluation of JTX-8064, an anti-LILRB2 antagonist antibody, for reprogramming tumor-associated macrophages
Immunology·2019
Abstract B30: Discovery and functional characterization of novel anti-PD-1 antibodies using ex vivo cell-based assays, single-cell immunoprofiling, and in vivo studies in humanized mice
Cancer Research·2016· 4 cited
Abstract 2224: Discovery, development and characterization of a new class of therapeutic anti-PD-1 antibody
Cancer Research·2016
Abstract 4871: Two novel anti-PD-1 antibodies, 244C8 and 388D4, elicit <i>in vivo</i> antitumor efficacy in a lung PDX tumorgraft in immuno-humanized NSG mice
Cancer Research·2016· 1 cited
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors
Biochemical Journal·2014· 22 cited
Selectively targeting an inactive conformation of IL-2-induced T cell kinase by allosteric inhibitors.
2014· 2 cited
Covalent Inhibitors of Interleukin-2 Inducible T Cell Kinase (Itk) with Nanomolar Potency in a Whole-Blood Assay
Journal of Medicinal Chemistry·2012· 77 citedOpen Access
Osteogenic Effects of a Potent Src-over-Abl-Selective Kinase Inhibitor in the Mouse
Journal of Pharmacology and Experimental Therapeutics·2011· 3 cited
In vitro potency, pharmacokinetic profiles and pharmacological activity of optimized anti-IL-21R antibodies in a mouse model of lupus
mAbs·2010· 49 citedOpen Access
Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys
Journal of Translational Medicine·2010· 19 citedOpen Access
hKSR-2 inhibits MEKK3-activated MAP kinase and NF-κB pathways in inflammation
Biochemical and Biophysical Research Communications·2005· 23 cited
Temporal associations between interleukin 22 and the extracellular domains of IL-22R and IL-10R2
International Immunopharmacology·2004· 66 cited
Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss
Genomics·2003· 172 cited
[26] A genetic selection for isolating cDNA clones that encode signal peptides
Methods in enzymology on CD-ROM/Methods in enzymology·1999· 14 cited
A genetic selection for isolating cDNAs encoding secreted proteins
Gene·1997· 337 cited

Frequent Co-authors

Edward C. Stack(4), Donald R. Shaffer(4), Monica Gostissa(4), Kenneth Jacobs(3), David C. Limburg(3), Nicole Caspers(3), Seungil Han(3), Ann Aulabaugh(3), Ravi G. Kurumbail(3), Subarna Shakya(3), Robert Czerwiński(3), Nilufer P. Seth(3), Quintus G. Medley(3), Margaret Willer(3), Sheila Ranganath(3), Thomas J. McQuade(3), Sri Vadde(3), Bin Feng(3), M. Isabel Chiu(3), Lisa A. Collins‐Racie(2)