Sam C. Nalle

Alector (United States) — United States

Medicine · Health Sciences

12h-index1.7kcitations29works0.02yr avg
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Research Topics

Hematopoietic Stem Cell Transplantation(6), Inflammatory Bowel Disease(5), Glycosylation and Glycoproteins Research(5), Barrier Structure and Function Studies(5), Immune cells in cancer(4)

Publications29 total

The multi-Siglec inhibitor AL009 reprograms suppressive macrophages and activates innate and adaptive tumor immunity
2023· 1 citedOpen Access
114 Characterization of suppressive myeloid cells in solid tumors to refine disease selection in a Phase 1 study of the multi-Siglec inhibitor AL009
Regular and Young Investigator Award Abstracts·2022Open Access
Targeting the Siglec–Sialic Acid Immune Axis in Cancer: Current and Future Approaches
Cancer Immunology Research·2022· 97 citedOpen Access
Abstract 613: AL009 is a multi-Siglec inhibitor engineered to bind myeloid cells that enhances innate and adaptive immunity to cancer
Cancer Research·2022· 1 cited
875 AL009, a fusion protein and multi-Siglec inhibitor, repolarizes suppressive myeloid cells and potentiates anti-cancer effects
Regular and Young Investigator Award Abstracts·2021· 1 citedOpen Access
Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation
PLoS ONE·2020· 26 citedOpen Access
Aquaporin-3 regulates endosome-to-cytosol transfer via lipid peroxidation for cross presentation
2020· 7 citedOpen Access
Graft-versus-host disease propagation depends on increased intestinal epithelial tight junction permeability
Journal of Clinical Investigation·2019· 63 citedOpen Access
Molecular correlates differentiate response to atezolizumab (atezo) + bevacizumab (bev) vs sunitinib (sun): Results from a phase III study (IMmotion151) in untreated metastatic renal cell carcinoma (mRCC)
Annals of Oncology·2018· 72 cited
FRET Reagent Reveals the Intracellular Processing of Peptide-Linked Antibody–Drug Conjugates
Bioconjugate Chemistry·2018· 34 cited
Analysis of pancreatic disease in zebrafish
Methods in cell biology·2016· 7 cited
Therapeutic targeting of the intestinal barrier in inflammatory bowel disease and graft-versus-host disease
˜The œbiomedical & life sciences collection.·2015
Abstract 211: A novel FRET assay for the intracellular activation of ADC linkers
Cancer Research·2015
Intestinal barrier loss as a critical pathogenic link between inflammatory bowel disease and graft-versus-host disease
Mucosal Immunology·2015· 131 citedOpen Access
Recipient NK cell inactivation and intestinal barrier loss are required for MHC-matched graft-versus-host disease
Science Translational Medicine·2014· 52 citedOpen Access
TNFR2 Activates MLCK-Dependent Tight Junction Dysregulation to Cause Apoptosis-Mediated Barrier Loss and Experimental Colitis
Gastroenterology·2013· 382 citedOpen Access
Endothelial and Epithelial Barriers in Graft-Versus-Host Disease
Advances in experimental medicine and biology·2013· 9 cited
Knock-Down of Irbit (Inositol-1,4,5-Trisphosphate Receptor Binding Protein Released With IP3) Increases Epithelial Paracellular Permeability
Gastroenterology·2011
Intestinal Damage and Myosin Light Chain Kinase (MLCK)-Dependent Epithelial Barrier Dysfunction Are Vital to Minor Mismatch Graft-Versus-Host Disease
Gastroenterology·2011· 1 cited
Pretransplant conditioning is required for minor but not major mismatch graft-versus-host disease: a vital role for intestinal damage (169.15)
The Journal of Immunology·2011
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Frequent Co-authors

Jerrold R. Turner(13), Peter A. Savage(6), Nora Joseph(4), Cécile Chalouni(4), Gurminder Singh(3), Ira Mellman(3), Helen Lam(3), Spencer C. Liang(3), Arnon Rosenthal(3), Daniel Maslyar(3), Liping Su(2), Le Shen(2), Erika A. Sullivan(2), Clara Abraham(2), Galina Khramtsova(2), Yang‐Xin Fu(2), Daniel Maslyar(2), Karen L. Edelblum(2), Byoung-Chul Lee(2), Sophia Doll(2)