Thomas H. Sisson

University of Michigan — United States

Medicine · Health Sciences

37h-index5.2kcitations93works3.12yr avg
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Research Topics

Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis(46), Neonatal Respiratory Health Research(22), Protease and Inhibitor Mechanisms(19), Pulmonary Hypertension Research and Treatments(12), Occupational exposure and asthma(9)

Publications93 total

A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model
JCI Insight·2026Open Access
Targeting Plasminogen Activator Inhibitor-1 with a Novel Small Molecule Inhibitor Attenuates Lung Fibrosis
2025Open Access
Degradation of oxidized phospholipids by lysosomal phospholipase A2 regulates pulmonary fibrosis
American Journal of Physiology-Lung Cellular and Molecular Physiology·2025· 2 citedOpen Access
PAI-1 interaction with sortilin-related receptor 1 is required for lung fibrosis
JCI Insight·2025· 3 citedOpen Access
PAI-1 Interaction with Sortilin Related Receptor-1 is Required for Lung Fibrosis
2024· 1 citedOpen Access
Lysosomal Phospholipase A2 Reduces Lipid Accumulation and Modulates Macrophages Profibrotic Phenotype in Lung Fibrosis
2024
SORL1 is a receptor for tau that promotes tau seeding
Journal of Biological Chemistry·2024· 19 citedOpen Access
Plasminogen Activator Inhibitor Protease Domain Drives Venous Fibrosis
Journal of Vascular Surgery Venous and Lymphatic Disorders·2024Open Access
CD36/Lyn kinase interactions within macrophages promotes pulmonary fibrosis in response to oxidized phospholipid
Respiratory Research·2023· 18 citedOpen Access
A Case of Suspected Mitochondrial Dysfunction Presenting in an Adult
2023
Defibrotide Therapy for SARS-CoV-2 ARDS
CHEST Journal·2022· 14 citedOpen Access
Table of Contents
American Journal Of Pathology·2022Open Access
Sustained Club Cell Injury in Mice Induces Histopathologic Features of Deployment-Related Constrictive Bronchiolitis
American Journal Of Pathology·2021· 8 citedOpen Access
Defibrotide Therapy for Sars CoV2 Acute Respiratory Distress Syndrome
Blood·2021Open Access
Sustained Lung Club Cell Injury in Mice Induces Peribronchiolar Macrophage Accumulation and Fibrosis - Implications for Deployment-Related Chronic Bronchiolitis
2020Open Access
Diverse Injury Pathways Induce Alveolar Epithelial Cell CCL2/12, Which Promotes Lung Fibrosis
American Journal of Respiratory Cell and Molecular Biology·2020· 88 citedOpen Access
Venous Thromboembolism in the Intensive Care Unit
2020
Urokinase Plasminogen Activator Overexpression Reverses Established Lung Fibrosis
Thrombosis and Haemostasis·2019· 28 citedOpen Access
Bioanalytical Raman Spectral Cytometry of Alveolar Macrophages for the Quantitative Study of Idiopathic Pulmonary Fibrosis
2019· 1 cited
CD 36 Promotes Lung Fibrosis in Response to Oxidized Phospholipids: Role of Lung Macrophages?
2019
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Frequent Co-authors

Richard H. Simon(23), Jeffrey C. Horowitz(17), Natalya Subbotina(10), Eric S. White(10), Bethany B. Moore(10), Noboru Hattori(10), Kevin K. Kim(10), Iyabode O. Ajayi(7), Steven K. Huang(6), John J. Osterholzer(6), Paul J. Christensen(5), Daniel J. Tschumperlin(4), Andrew K. Cunningham(4), Victor J. Thannickal(4), Cory M. Hogaboam(4), Kevin R. Flaherty(4), Peter Higgins(4), Kerstin E. Hanson(4), Timothy J. Koh(4), Anthony J. Courey(3)