Jen C. C. Hume

National Institute of Allergy and Infectious Diseases — United States

Medicine · Health Sciences

17h-index852citations24works2.32yr avg
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Research Topics

Malaria Research and Control(18), Mosquito-borne diseases and control(14), Invertebrate Immune Response Mechanisms(5), Computational Drug Discovery Methods(3), Research on Leishmaniasis Studies(3)

Publications24 total

Epitope-specific competitive ELISA predicts malaria transmission-blocking vaccine Pfs230D1 activity measured in standard membrane feeding assay
JCI Insight·2026Open Access
A Vaccine to Block <i>Plasmodium falciparum</i> Transmission
NEJM Evidence·2025· 7 cited
Correction: Immunogenic Salivary Proteins of Triatoma infestans: Development of a Recombinant Antigen for the Detection of Low-Level Infestation of Triatomines
PLoS neglected tropical diseases·2024Open Access
Malaria transmission-blocking vaccines Pfs230D1-EPA and Pfs25-EPA in Alhydrogel in healthy Malian adults; a phase 1, randomised, controlled trial
The Lancet Infectious Diseases·2023· 46 citedOpen Access
Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine
npj Vaccines·2023· 20 citedOpen Access
Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity
Nature·2021· 110 citedOpen Access
Ultra-sensitive RDT performance and antigen dynamics in a high-transmission Plasmodium falciparum setting in Mali
Malaria Journal·2020· 22 citedOpen Access
Chemoprophylaxis Vaccination: Phase I Study to Explore Stage-specific Immunity to Plasmodium falciparum in US Adults
Clinical Infectious Diseases·2019· 13 citedOpen Access
Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections
American Journal of Tropical Medicine and Hygiene·2019· 60 citedOpen Access
Optimizing Direct Membrane and Direct Skin Feeding Assays for Plasmodium falciparum Transmission-Blocking Vaccine Trials in Bancoumana, Mali
American Journal of Tropical Medicine and Hygiene·2017· 17 citedOpen Access
Utilizing direct skin feeding assays for development of vaccines that interrupt malaria transmission: A systematic review of methods and case study
Vaccine·2016· 19 citedOpen Access
Host-based Prophylaxis Successfully Targets Liver Stage Malaria Parasites
Molecular Therapy·2015· 32 citedOpen Access
Development of potent and selective Plasmodium falciparum calcium-dependent protein kinase 4 (PfCDPK4) inhibitors that block the transmission of malaria to mosquitoes
European Journal of Medicinal Chemistry·2014· 63 cited
A rapid and scalable density gradient purification method for Plasmodium sporozoites
Malaria Journal·2012· 101 citedOpen Access
A transgenic Plasmodium falciparum NF54 strain that expresses GFP–luciferase throughout the parasite life cycle
Molecular and Biochemical Parasitology·2012· 70 cited
Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria
Arteriosclerosis Thrombosis and Vascular Biology·2011· 32 cited
Susceptibility of Anopheles stephensi to Plasmodium gallinaceum: A Trait of the Mosquito, the Parasite, and the Environment
PLoS ONE·2011· 8 citedOpen Access
Immunogenic Salivary Proteins of Triatoma infestans: Development of a Recombinant Antigen for the Detection of Low-Level Infestation of Triatomines
PLoS neglected tropical diseases·2009· 36 citedOpen Access
Antibody responses of domestic animals to salivary antigens of Triatoma infestans as biomarkers for low-level infestation of triatomines
International Journal for Parasitology·2009· 41 citedOpen Access
Molecular Evolution of Immune Genes in the Malaria Mosquito Anopheles gambiae
PLoS ONE·2009· 45 citedOpen Access
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Frequent Co-authors

Sara A. Healy(9), Patrick E. Duffy(8), Stefan H. I. Kappe(6), Mark Kennedy(5), Issaka Sagara(5), Sean C. Murphy(4), Peter F. Billingsley(4), Mahamadoun H. Assadou(4), Mamadou B. Coulibaly(4), Ogobara K. Doumbo(4), José M. C. Ribeiro(4), Alemush Imeru(3), Jillian Neal(3), Irfan Zaidi(3), Ashley M. Vaughan(3), Sebastian A. Mikolajczak(3), Daman Sylla(3), Sékou F. Traorè(3), Alexandra Schwarz(3), J. Sternberg(3)