Jon M. Huibregtse

The University of Texas at Austin — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

55h-index18.6kcitations115works2.12yr avg
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Research Topics

Ubiquitin and proteasome pathways(46), Cancer-related Molecular Pathways(31), Cervical Cancer and HPV Research(17), interferon and immune responses(14), Virus-based gene therapy research(12)

Publications115 total

BPS2026 – Epsin1 enforces a condensation dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis
Biophysical Journal·2026
Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles
Cell Reports·2025Open Access
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Molecular Cell·2025· 1 citedOpen Access
Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis
Nature Communications·2025· 1 citedOpen Access
Epsin1 enforces a condensation-dependent checkpoint for ubiquitylated cargo during clathrin-mediated endocytosis
2025· 1 citedOpen Access
BPS2025 - Ubiquitylation-driven receptor selection at endocytic sites: A competitive filtering mechanism
Biophysical Journal·2025
BPS2025 - Intrinsic disorder as an organizing principle for endocytosis
Biophysical Journal·2025
BPS2025 - Intrinsic disorder as an organizing principle for endocytosis
Biophysical Journal·2025
Poly-ubiquitylated transmembrane proteins outcompete other cargo for limited space inside clathrin-coated vesicles
2024Open Access
Native Mass Spectrometry Reveals Binding Interactions of SARS-CoV-2 PLpro with Inhibitors and Cellular Targets
ACS Infectious Diseases·2024· 3 citedOpen Access
Native mass spectrometry reveals binding interactions of SARS-CoV-2 PLpro with inhibitors and ISG15
2024
Ubiquitin-driven protein condensation stabilizes clathrin-mediated endocytosis
PNAS Nexus·2024· 12 citedOpen Access
Native mass spectrometry reveals binding interactions of SARS-CoV-2 PLpro with inhibitors and ISG15
2024· 1 citedOpen Access
Cellular targets and lysine selectivity of the HERC5 ISG15 ligase
iScience·2024· 11 citedOpen Access
Native mass spectrometry reveals binding interactions of SARS-CoV-2 PLpro with inhibitors and ISG15
2023· 2 citedOpen Access
Ubiquitin-driven protein condensation initiates clathrin-mediated endocytosis
2023· 6 citedOpen Access
6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro
iScience·2021· 59 citedOpen Access
Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells
PLoS Biology·2020· 77 citedOpen Access
6-Thioguanine blocks SARS-CoV-2 replication by inhibition of PLpro protease activities
2020· 36 citedOpen Access
Modulation of Extracellular ISG15 Signaling by Pathogens and Viral Effector Proteins
Cell Reports·2020· 103 citedOpen Access
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Frequent Co-authors

Peter M. Howley(16), Martin Scheffner(12), Sylvie Beaudenon(8), Nancy Lyon(5), Melissa L. Kelley(4), Guangli Wang(4), Younghoon Kee(4), Guangli Wang(3), Larissa A. Durfee(3), Robert M. Krug(3), Shunsuke Nakagawa(3), Karl Münger(3), Hyung Cheol Kim(3), Caleb D. Swaim(3), Chen Zhao(2), Ronald N. Harty(2), Melissa E. Brown(2), Judy A. Mietz(2), Anahita Dastur(2), Andrea L. Talis(2)