William J. Griffiths

Swansea University — United Kingdom

Medicine · Health Sciences

65h-index15.7kcitations422works5.52yr avg
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Research Topics

Cholesterol and Lipid Metabolism(120), Mass Spectrometry Techniques and Applications(105), Drug Transport and Resistance Mechanisms(66), Metabolomics and Mass Spectrometry Studies(54), Analytical Chemistry and Chromatography(45)

Publications422 total

24S-Hydroxycholesterol: A potential brain-derived biomarker of Huntington’s Disease
2025Open Access
Deletion of <i>CH25H</i> and <i>LIPA</i> Genes in Human Abolishes Biosynthesis of 25-Hydroxycholesterol but not of 7α,25-Dihydroxysterols and Enhances Non-enzymatic Cholesterol Oxidation: Metabolic Changes are Partially Reversed by Hematopoietic Stem Cell Transplant <sup>‡</sup>
2025· 1 citedOpen Access
Intra- and inter-individual variation of the human lipidome
TrAC Trends in Analytical Chemistry·2025Open Access
Rare Cholesterol Related Disorders – A Sterolomic Library for Diagnosis and Monitoring of Diseases
2025Open Access
Brain cholesterol metabolites cause significant neurodegeneration in human iPSC-derived neurons
2025Open Access
SAT-338-YI The role of metabolic factors in alpha-1 antitrypsin deficiency
Journal of Hepatology·2025
In Memoriam: Jan B Sjövall, MD, PhD, (1928–2024)
Journal of Lipid Research·2025Open Access
WED-323 Fazirsiran for alpha-1 antitrypsin deficiency-associated liver disease: long-term efficacy and safety results from a phase 2 extension study
Journal of Hepatology·2025
Sterol imbalances and cholesterol‐24‐hydroxylase dysregulation is linked to the underlying progression of multiple sclerosis
Brain Pathology·2025· 2 citedOpen Access
Role of Bile Acid Pathway Intermediates in Pathology of Cerebrotendinous Xanthomatosis (CTX)
2025Open Access
P18 What are patients saying? Results from the WDSG-UK (Wilson’s disease support group) survey
2024
Convergent evolution of somatic escape variants in <i>SERPINA1</i> in the liver in alpha-1 anti-trypsin deficiency
2024· 1 citedOpen Access
The lipidomics reporting checklist a framework for transparency of lipidomic experiments and repurposing resource data
Journal of Lipid Research·2024· 34 citedOpen Access
WED-135-YI Impact of metabolic alterations on liver phenotype of patients with homozygous alpha-1 antitrypsin deficiency (Pi*ZZ)
Journal of Hepatology·2024
Establishing an oxysterol signature in neutrophils following initiation of oxidative burst
Free Radical Biology and Medicine·2024
Cholesterol 25-hydroxylase Promotes Survival and Modulates Immune Cell Recruitment to the Lung During Mycobacterium Tuberculosis Infection
2024
11th ENOR meeting: Oxysterols in human health and diseases
The Journal of Steroid Biochemistry and Molecular Biology·2024
Brain cholesterol and Alzheimer's disease: challenges and opportunities in probe and drug development
Brain·2024· 43 citedOpen Access
CYP46A1-mediated cholesterol turnover induces sex-specific changes in cognition and counteracts memory loss in ovariectomized mice
Science Advances·2024· 24 citedOpen Access
Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development
iScience·2023· 8 citedOpen Access
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Frequent Co-authors

Yuqin Wang(21), Jan Sjövall(15), Suya Liu(7), Peter J. Crick(7), Gerhard Liebisch(5), Harald Köfeler(5), Valerie B. O’Donnell(5), Christer S. Ejsing(4), Markus R. Wenk(4), Eylan Yutuc(4), Karl Bodin(4), Michael J.O. Wakelam(3), Edward A. Dennis(3), Maria Fedorova(3), Steven Watterson(3), Peter Ghazal(3), Robert Ahrends(3), John A. Bowden(3), Michal Holčapek(3), Kim Ekroos(3)