Jonathan R. Hart

Scripps Research Institute — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

27h-index3.0kcitations66works0.02yr avg
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Research Topics

PI3K/AKT/mTOR signaling in cancer(20), Cancer-related molecular mechanisms research(13), Chronic Lymphocytic Leukemia Research(10), Protein Kinase Regulation and GTPase Signaling(8), RNA Research and Splicing(8)

Publications66 total

Characterization of four cluster A1 <i>Mycobacterium</i> phage genomes, Applejack, Hermia, LilBib, and QTRlifeCrisis
Microbiology Resource Announcements·2025Open Access
The constitutive oncogenic and signaling activities of phosphatidylinositol 3-kinase (PI3K) isoforms p110β and p110δ
2025Open Access
Long Non-Coding RNAs as “MYC Facilitators”
Pathophysiology·2023· 2 citedOpen Access
Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα)
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer·2023· 5 citedOpen Access
The MYC-regulated lncRNA LNROP (ENSG00000254887) enables MYC-driven cell proliferation by controlling the expression of OCT2
Cell Death and Disease·2023· 6 citedOpen Access
Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα
Proceedings of the National Academy of Sciences·2022· 47 citedOpen Access
Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα
Proceedings of the National Academy of Sciences·2022· 16 citedOpen Access
Abstract 1535: Novel lncRNA ENSG00000254887 is a key factor for MYC-driven cell proliferation
Cancer Research·2022
Abstract 671: Cryo-electronmicroscopy of PI3K reveals additional regulatory features
Cancer Research·2022
Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation
Proceedings of the National Academy of Sciences·2021· 39 citedOpen Access
Synthetic fluorescent MYC probe: Inhibitor binding site elucidation and development of a high-throughput screening assay
Bioorganic & Medicinal Chemistry·2021· 8 citedOpen Access
Hereditary vs Familial Pancreatic Cancer: Associated Genetic Syndromes and Clinical Perspective
ONCOLOGY·2020· 7 cited
An MXD1-derived repressor peptide identifies noncoding mediators of MYC-driven cell proliferation
Proceedings of the National Academy of Sciences·2020· 47 citedOpen Access
PIK3CA Cooperates with KRAS to Promote MYC Activity and Tumorigenesis via the Bromodomain Protein BRD9
Cancers·2019· 36 citedOpen Access
Isoform-specific activities of the regulatory subunits of phosphatidylinositol 3-kinases – potentially novel therapeutic targets
Expert Opinion on Therapeutic Targets·2018· 23 citedOpen Access
Selenocysteine-Specific Mass Spectrometry Reveals Tissue-Distinct Selenoproteomes and Candidate Selenoproteins
Cell chemical biology·2018· 46 citedOpen Access
Comprehensive RNA-Sequencing Analysis in Serum and Muscle Reveals Novel Small RNA Signatures with Biomarker Potential for DMD
Molecular Therapy — Nucleic Acids·2018· 56 citedOpen Access
Synthetic molecules for disruption of the MYC protein-protein interface
Bioorganic & Medicinal Chemistry·2018· 11 citedOpen Access
Domain analysis reveals striking functional differences between the regulatory subunits of phosphatidylinositol 3-kinase (PI3K), p85α and p85β
Oncotarget·2017· 28 citedOpen Access
tsRNA signatures in cancer
Proceedings of the National Academy of Sciences·2017· 286 citedOpen Access
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Frequent Co-authors

Peter K. Vogt(39), Lynn Ueno(11), Marc S. Weinberg(6), Kim D. Janda(5), Kevin V. Morris(5), John R. Yates(5), Thomas C. Roberts(4), Jacqueline K. Barton(4), Marco Gymnopoulos(4), Qingtong Zhou(4), Dehua Yang(4), Ming‐Wei Wang(4), Carlo M. Croce(3), Nicola Valeri(3), Chiara Braconi(3), Pierluigi Gasparini(3), Francesca Lovat(3), Giovanni Lanza(3), Roberta Gafà(3), Wendy L. Frankel(3)