Brandon Novy

University of North Carolina at Chapel Hill — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

3h-index55citations18works3.02yr avg
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Research Topics

Receptor Mechanisms and Signaling(6), Computational Drug Discovery Methods(4), Protein Structure and Dynamics(3), RNA and protein synthesis mechanisms(3), Cellular transport and secretion(3)

Publications18 total

Expansion of DNA-Encoded Library Hits Using Generative Chemistry and Ultra-Large Compound Catalogs
2025Open Access
Conserved Filovirus Proteins as Targets of Broad-Spectrum Antivirals
2025· 1 citedOpen Access
A Hit Prioritization Strategy for Compound Library Screening Using LiP-MS and Molecular Dynamics Simulations Applied to KRas G12D Inhibitors
Analytical Chemistry·2025Open Access
Development of Next Generation Cell-Permeable Peptide Inhibitors for the Oncological Target MAGE-A4
Journal of Medicinal Chemistry·2025· 1 cited
DNAJC13 localization to endosomes is opposed by its J domain and its disordered C-terminus
Molecular Biology of the Cell·2025Open Access
A Hit Prioritization Strategy for Compound Library Screening Using LiP-MS and Molecular Dynamics Simulations Applied to KRas G12D Inhibitors
2025· 1 citedOpen Access
Characterization of the KRas G12D-inhibitor interactions by HDX-MS and molecular dynamics simulations
2025Open Access
DNAJC13 Regulates GPCR Sorting at Endosomes (Abstract ID: 161875)
Journal of Pharmacology and Experimental Therapeutics·2025
Identification of Proteins Controlling Mu Opioid Receptor Recycling Using a Novel Chemical Biology Platform (Abstract ID: 157192)
Journal of Pharmacology and Experimental Therapeutics·2025
Open-Source DNA-Encoded Library informatics Package for Design, Decoding, and Analysis: DELi
2025· 2 citedOpen Access
Characterization of the KRas G12D-inhibitor interactions by differential HDX-MS and molecular dynamics simulations
Computational and Structural Biotechnology Journal·2025· 1 citedOpen Access
DNAJC13 localization to endosomes is opposed by its J domain and its disordered C- terminal tail
2024Open Access
Retromer Opposes Opioid-Induced Downregulation of the Mu Opioid Receptor
2024Open Access
An engineered trafficking biosensor reveals a role for DNAJC13 in DOR downregulation
Nature Chemical Biology·2024· 9 citedOpen Access
Profiling the proximal proteome of the activated μ-opioid receptor
Nature Chemical Biology·2024· 30 citedOpen Access
A genome-wide CRISPR interference screen using an engineered trafficking biosensor reveals a role for RME-8 in opioid receptor regulation
2022· 2 citedOpen Access
Profiling the proximal proteome of the mu opioid receptor identifies novel regulators of receptor signaling and trafficking
2022· 8 citedOpen Access
A genome‐wide CRISPR interference screen using a novel reporter for endo‐lysosomal trafficking reveals a role for RME‐8 in opioid receptor regulation
The FASEB Journal·2021

Frequent Co-authors

Braden T. Lobingier(10), Hayden Adoff(7), Monica De Maria(5), Konstantin I. Popov(5), Mark von Zastrow(4), Aleksandra Dagunts(4), Emily Holland(4), Evgeniy V. Petrotchenko(4), Jason B. Cross(4), Roopa Thapar(4), Christoph H. Borchers(4), Nikoleta G. Tsvetanova(3), Kenneth H. Pearce(3), Benjamin J. Polacco(2), Emily E. Blythe(2), Nohely Abreu(2), Prachi Khare(2), Matthew K. Howard(2), Alberto J. Gonzalez-Hernandez(2), Jiewei Xu(2)