Yao‐Hao Xu

Sun Yat-sen University — China

Medicine · Health Sciences

11h-index579citations15works0.02yr avg
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Research Topics

Liver Disease Diagnosis and Treatment(4), Metabolism, Diabetes, and Cancer(3), Adipose Tissue and Metabolism(3), DNA Repair Mechanisms(2), DNA and Nucleic Acid Chemistry(2)

Publications15 total

Design, synthesis and evaluation of 2-pyrimidinylindole derivatives as anti-obesity agents by regulating lipid metabolism
European Journal of Medicinal Chemistry·2023· 11 cited
Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer
Journal of Medicinal Chemistry·2023· 14 cited
Fluorescent Quinolinium Derivative as Novel Mitochondria Probe and Function Modulator by Targeting Mitochondrial RNA
Molecules·2023· 4 citedOpen Access
Matrine counteracts obesity in mice via inducing adipose thermogenesis by activating HSF1/PGC-1α axis
Pharmacological Research·2022· 21 citedOpen Access
Palladium oxidative addition complex-enabled synthesis of amino-substituted indolyl-4(3<i>H</i>)-quinazolinones and their antitumor activity evaluation
Organic & Biomolecular Chemistry·2021· 1 cited
A novel HSF1 activator ameliorates non‐alcoholic steatohepatitis by stimulating mitochondrial adaptive oxidation
British Journal of Pharmacology·2021· 23 cited
Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis
Gut Microbes·2021· 313 citedOpen Access
Gut Akkermansia muciniphila ameliorates non-alcoholic fatty liver disease by L-aspartate via interaction with liver
2020· 1 cited
Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors
Journal of Medicinal Chemistry·2020· 46 citedOpen Access
Discovery of a promising agent IQZ23 for the treatment of obesity and related metabolic disorders
European Journal of Medicinal Chemistry·2020· 13 cited
Pyridocarbazole alkaloids from Ochrosia borbonica: lipid-lowering agents inhibit the cell proliferation and adipogenesis of 3T3-L1 adipocyte via intercalating into supercoiled DNA
Chinese Journal of Natural Medicines·2019· 3 cited
Bouchardatine analogue alleviates non‐alcoholic hepatic fatty liver disease/non‐alcoholic steatohepatitis in high‐fat fed mice by inhibiting ATP synthase activity
British Journal of Pharmacology·2019· 38 citedOpen Access
Bouchardatine suppresses rectal cancer in mice by disrupting its metabolic pathways via activating the SIRT1-PGC-1α-UCP2 axis
European Journal of Pharmacology·2019· 17 cited
Design, synthesis and biological evaluation of novel bouchardatine analogs as potential inhibitors of adipogenesis/lipogenesis in 3T3-L1 adipocytes
European Journal of Medicinal Chemistry·2018· 15 cited
New Disubstituted Quindoline Derivatives Inhibiting Burkitt’s Lymphoma Cell Proliferation by Impeding <i>c-MYC</i> Transcription
Journal of Medicinal Chemistry·2017· 59 cited

Frequent Co-authors

Zhi‐Shu Huang(14), Yong Rao(12), Yu‐Tao Hu(10), Ji‐Ming Ye(8), Shi‐Yao Guo(6), Dandan Zhao(6), Bingbing Song(6), Jia‐Heng Tan(6), Qingjiang Li(5), Chan Li(4), Shi‐Liang Huang(4), Shuo‐Bin Chen(4), Tian‐Miao Ou(3), Qinqin Song(3), Xu Zhao(3), Zhi Jiang(3), Shuo-Bin Chen(3), Zhiqi Kuang(2), Zhi Jiang(2), Zhenhuang Ge(2)