Diego Esposito

The Francis Crick Institute — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.7kcitations60works1.42yr avg
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Research Topics

Ubiquitin and proteasome pathways(14), interferon and immune responses(10), Bacterial Genetics and Biotechnology(5), Protein Kinase Regulation and GTPase Signaling(5), Salmonella and Campylobacter epidemiology(5)

Publications60 total

Structure and mechanism of the HECT ligase HECTD3
Nature Communications·2026Open Access
Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2
RSC Chemical Biology·2025· 1 citedOpen Access
Author response for "Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2"
2025
Conformational dynamics of the bacterial E3 ligase SspH1
Journal of Biological Chemistry·2025· 1 citedOpen Access
Covalent fragment screening to inhibit the E3 ligase activity of bacterial NEL enzymes SspH1 and SspH2
2025Open Access
Conformational dynamics of the bacterial E3 ligase SspH1
2025Open Access
Bacterial effectors mediate kinase reprogramming through mimicry of conserved eukaryotic motifs
EMBO Reports·2025Open Access
Author response for "Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination"
2025
Author response for "Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination"
2025
Identification of RING E3 pseudoligases in the TRIM protein family
Nature Communications·2025· 9 citedOpen Access
<i>Salmonella</i> effector kinase SteC is activated by host-mediated phosphorylation
2025Open Access
Discovery and optimisation of a covalent ligand for TRIM25 and its application to targeted protein ubiquitination
Chemical Science·2025· 6 citedOpen Access
‘Identification of RING E3 pseudoligases in the TRIM protein family’
2024Open Access
Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity
Nature Communications·2022· 22 citedOpen Access
Characterisation of HOIP RBR E3 ligase conformational dynamics using integrative modelling
Scientific Reports·2022· 3 citedOpen Access
Does it take two to tango? RING domain self-association and activity in TRIM E3 ubiquitin ligases
Biochemical Society Transactions·2020· 68 citedOpen Access
Characterisation of class VI TRIM RING domains: linking RING activity to C-terminal domain identity
Life Science Alliance·2019· 34 citedOpen Access
Structure–function analyses of the bacterial zinc metalloprotease effector protein GtgA uncover key residues required for deactivating NF-κB
Journal of Biological Chemistry·2018· 36 citedOpen Access
Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR
Biophysical Journal·2018· 11 citedOpen Access
Crystal structure of Salmonella zinc metalloprotease effector GtgA
2018
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Frequent Co-authors

Katrin Rittinger(19), Paul C. Driscoll(19), Richard Harris(10), Tom D. Bunney(6), Matilda Katan(6), Acely Garza-Garcı́a(6), Katherine A. McPhie(6), Jane Dudley-Fraser(5), Peter Gierschik(4), Pompea Del Vecchio(4), Guido Barone(4), Jonathan Pettinger(4), Jacob T. Bush(4), Mire Zloh(4), Sarah Maslen(4), Jay C. D. Hinton(3), John E. Ladbury(3), Michelle B. Josephs(3), Andrew Sankar(3), Claudia Walliser(3)