Tomáš Cihlář

Cambridge Health Alliance — United States

Medicine · Health Sciences

64h-index22.4kcitations233works5.62yr avg
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Research Topics

HIV/AIDS drug development and treatment(99), HIV Research and Treatment(72), SARS-CoV-2 and COVID-19 Research(52), COVID-19 Clinical Research Studies(31), HIV/AIDS Research and Interventions(30)

Publications233 total

Discovery of Lenacapavir: First-in-Class Twice-Yearly Capsid Inhibitor for HIV-1 Treatment and Pre-exposure Prophylaxis
Journal of Medicinal Chemistry·2025· 3 citedOpen Access
The Indispensable Value of Small-Molecule Antivirals in Epidemic and Pandemic Preparedness
Clinical Infectious Diseases·2025Open Access
Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys
Nature Communications·2025· 2 citedOpen Access
FRI-275 Characterization of antigen specificity of T cell responses and HBV neutralization activity in a cohort of patients who achieved HBV HBsAg loss
Journal of Hepatology·2025
Remdesivir postexposure prophylaxis limits measles-induced “immune amnesia” and measles antibody responses in macaques
JCI Insight·2025· 1 citedOpen Access
Impact of HIV-1 capsid polymorphisms on viral infectivity and susceptibility to lenacapavir
mBio·2025· 6 citedOpen Access
The oral drug obeldesivir protects nonhuman primates against lethal Ebola virus infection
Science Advances·2025· 8 citedOpen Access
Oral dosing of the nucleoside analog obeldesivir is efficacious against RSV infection in African green monkeys
2025· 1 citedOpen Access
Remdesivir is active <i>in vitro</i> against tick-borne encephalitis virus and selects for resistance mutations in the viral RNA-dependent RNA polymerase
Infectious Diseases·2025· 3 citedOpen Access
Activating PKC-ε induces HIV expression with improved tolerability
PLoS Pathogens·2025· 2 citedOpen Access
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates
Nature Medicine·2025· 16 citedOpen Access
A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques
Viruses·2024· 1 citedOpen Access
Antiviral target compound profile for pandemic preparedness
Nature Reviews Drug Discovery·2024· 3 citedOpen Access
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses
UNC Libraries·2024Open Access
Discovery of GS-7682, a Novel 4′-Cyano-Modified <i>C</i>-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
Journal of Medicinal Chemistry·2024· 12 citedOpen Access
The oral nucleoside prodrug GS-5245 is efficacious against SARS-CoV-2 and other endemic, epidemic, and enzootic coronaviruses
Science Translational Medicine·2024· 15 citedOpen Access
Discovery and Synthesis of GS-7682, a Novel Prodrug of a 4′-CN-4-Aza-7,9-Dideazaadenosine <i>C</i> -Nucleoside with Broad-Spectrum Potency Against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys
2024Open Access
Oral administration of obeldesivir protects nonhuman primates against <i>Sudan ebolavirus</i>
Science·2024· 30 citedOpen Access
Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability
Antimicrobial Agents and Chemotherapy·2024· 4 citedOpen Access
Characterization of the Cynomolgus Macaque Model of Marburg Virus Disease and Assessment of Timing for Therapeutic Treatment Testing
Viruses·2023· 5 citedOpen Access
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Frequent Co-authors

Adrian S. Ray(11), Joy Y. Feng(8), Richard L. Mackman(8), Robert Jordan(7), Kirsten M. Stray(7), S. Swaminathan(7), Andrew Mulato(7), Timothy P. Sheahan(6), Michael O. Clarke(6), Mark R. Denison(6), Ralph S. Baric(6), Dustin S. Siegel(6), Gabriel Birkuš(6), Stephen R. Yant(6), Edmund Ho(6), Darius Babusis(5), Danielle Porter(5), Roy Bannister(5), Hon C. Hui(5), Amy Sims(4)