Remo D. Spescha

University of Zurich — Switzerland

Immunology and Microbiology · Life Sciences

11h-index601citations17works0.02yr avg
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Research Topics

Atherosclerosis and Cardiovascular Diseases(9), Neuroinflammation and Neurodegeneration Mechanisms(6), MicroRNA in disease regulation(2), Alzheimer's disease research and treatments(2), Angiogenesis and VEGF in Cancer(2)

Publications17 total

Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 in ischaemia/reperfusion cerebral injury
Journal of Cerebral Blood Flow & Metabolism·2018· 26 citedOpen Access
P2494Deleterious role of endothelial lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) in ischemia/reperfusion-induced cerebral injury
European Heart Journal·2018Open Access
Endothelial LOX-1 activation differentially regulates arterial thrombus formation depending on oxLDL levels: role of the Oct-1/SIRT1 and ERK1/2 pathways
Cardiovascular Research·2017· 35 citedOpen Access
Reduced nitric oxide bioavailability mediates cerebroarterial dysfunction independent of cerebral amyloid angiopathy in a mouse model of Alzheimer’s disease
American Journal of Physiology-Heart and Circulatory Physiology·2016· 27 citedOpen Access
The MAP kinase JNK2 mediates cigarette smoke-induced arterial thrombosis
Thrombosis and Haemostasis·2016· 7 cited
Genetic ablation of the p66Shc adaptor protein reverses cognitive deficits and improves mitochondrial function in an APP transgenic mouse model of Alzheimer’s disease
Molecular Psychiatry·2016· 33 cited
Post-ischaemic silencing of p66<sup>Shc</sup>reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke
European Heart Journal·2015· 75 citedOpen Access
Adaptor Protein p66 <sup>Shc</sup> Mediates Hypertension-Associated, Cyclic Stretch–Dependent, Endothelial Damage
Hypertension·2014· 51 citedOpen Access
Endothelial Overexpression of LOX-1 increases stroke size in vivo
European Heart Journal·2013· 1 citedOpen Access
Post-ischemic in vivo p66shc silencing as a therapeutical strategy for ischemia/reperfusion brain injury
European Heart Journal·2013
Abstract 166: Endothelial Overexpression of LOX-1 Increases Stroke Size in vivo
Circulation Research·2013
Angiopoietin-like 4 and ischaemic stroke: a promising start
European Heart Journal·2013· 5 citedOpen Access
Peripheral Blood Monocyte Sirt1 Expression Is Reduced in Patients with Coronary Artery Disease
PLoS ONE·2013· 70 citedOpen Access
Deletion of the ageing gene p66Shc reduces early stroke size following ischaemia/reperfusion brain injury
European Heart Journal·2012· 84 citedOpen Access
Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease
Atherosclerosis·2011· 54 citedOpen Access
Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cells
Cardiovascular Research·2010· 103 citedOpen Access
Aging Induces Endothelial Dysfunction While Sparing Arterial Thrombosis
Arteriosclerosis Thrombosis and Vascular Biology·2010· 30 citedOpen Access

Frequent Co-authors

Giovanni G. Camici(15), Thomas F. Lüscher(13), Alexander Akhmedov(9), Stephan Sylvest Keller(6), Felix C. Tanner(5), Yi Shi(5), Roger M. Nitsch(5), Martin F. Reiner(5), Jürg H. Beer(5), Francesco Paneni(4), Gianluigi Savarese(4), Alexander Akhmedov(4), Luka Kulic(4), Maria Sessa(4), Alexander Breitenstein(3), Erik W. Holy(3), Christine Lohmann(3), Christian M. Matter(3), Giacomo Giacalone(3), Rebecca Derungs(3)