Hugo Seca

Universidade do Porto — Portugal

Biochemistry, Genetics and Molecular Biology · Life Sciences

13h-index6.6kcitations26works0.02yr avg
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Research Topics

MicroRNA in disease regulation(10), RNA Interference and Gene Delivery(5), Extracellular vesicles in disease(4), RNA modifications and cancer(4), Cell death mechanisms and regulation(3)

Publications24 total

Multiple Myeloma: Available Therapies and Causes of Drug Resistance
Cancers·2020· 215 citedOpen Access
Design and synthesis of new inhibitors of p53–MDM2 interaction with a chalcone scaffold
Arabian Journal of Chemistry·2016· 28 citedOpen Access
Data supporting the shedding of larger extracellular vesicles by multidrug resistant tumour cells
Data in Brief·2016· 11 citedOpen Access
Screening a Small Library of Xanthones for Antitumor Activity and Identification of a Hit Compound which Induces Apoptosis
Molecules·2016· 22 citedOpen Access
Multidrug resistant tumour cells shed more microvesicle-like EVs and less exosomes than their drug-sensitive counterpart cells
Biochimica et Biophysica Acta (BBA) - General Subjects·2015· 52 cited
Abstract 4433: P-gp-overexpressing MDR cells shed larger extracellular vesicles than their drug-sensitive counterparts
Cancer Research·2015
Effect of miR-128 in DNA Damage of HL-60 Acute Myeloid Leukemia Cells
Current Pharmaceutical Biotechnology·2014· 26 cited
MicroRNAs in Cancer Drug Resistance and Drug Sensitivity
2014· 1 cited
Mir-128 and DNA Damage In Acute Myeloid Leukemia
Blood·2013
The network of P-glycoprotein and microRNAs interactions
International Journal of Cancer·2013· 62 citedOpen Access
Targeting miR-21 Induces Autophagy and Chemosensitivity of Leukemia Cells
Current Drug Targets·2013· 106 cited
A Potent Thioxanthone which Induces Autophagy and Cell Death in a Melanoma Cell Line
Annals of Oncology·2013· 1 citedOpen Access
Poster session 3. Drug profiles - preclinical
Annals of Oncology·2013
Sulfated Small Molecules Targeting <scp>EBV</scp> in <scp>B</scp>urkitt Lymphoma: From <i>In Silico</i> Screening to the Evidence of <i>In Vitro</i> Effect on Viral Episomal <scp>DNA</scp>
Chemical Biology & Drug Design·2013· 13 citedOpen Access
Antimir-21 Causes Autophagy in the K562 Cell Line and Sensitizes Cells to the Effect of Doxorubicin and Etoposide
Blood·2012· 1 cited
439 Evidence for the Induction of Autophagy by AntimiR-21
European Journal of Cancer·2012Open Access
Simultaneous targeting of P‐gp and XIAP with siRNAs increases sensitivity of P‐gp overexpressing CML cells to imatinib
Hematology·2011· 17 cited
Treatment of Akata EBV-Positive Cells with Doxorubicin Causes More EBV Reactivation than Treatment with Etoposide
Chemotherapy·2011· 15 cited
EBV interferes with the sensitivity of Burkitt lymphoma Akata cells to etoposide
Journal of Cellular Biochemistry·2010· 7 cited
Insights into the <i>In Vitro</i> Antitumor Mechanism of Action of a New Pyranoxanthone
Chemical Biology & Drug Design·2010· 44 citedOpen Access
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Frequent Co-authors

M. Helena Vasconcelos(24), Raquel T. Lima(21), José E. Guimarães(9), Vanessa Lopes-Rodrigues(7), Diana Sousa(7), Emı́lia Sousa(7), Andreia Palmeira(6), Gabriela M. Almeida(6), Madalena Pinto(6), Rui Bergantim(3), Alessio Di Luca(3), Paula Meleady(3), Michael Henry(3), Robert O’Connor(3), Ana M. Oliveira Paiva(3), Manuel Sobrinho‐Simões(3), Kantima Choosang(3), Pannee Pakkong(3), María Säo José Nascimento(3), Miguel X. Fernandes(2)